Split 'aromatic-L-amino-acid decarboxylase activity ; GO:0004058' (EC:4.1.1.28)?

[gocentral]

There's two reactions listed for EC:4.1.1.28, and a different definition in the corresponding GO term, GO:0004058:

http://www.chem.qmul.ac.uk/iubmb/enzyme/EC4/1/1/28.html Reaction: (1) L-dopa = dopamine + CO2 (2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2

aromatic-L-amino-acid decarboxylase activity ; GO:0004058 Catalysis of the reaction: L-tryptophan = tryptamine + CO2. EC:4.1.1.28

I think 3 new child terms could be created to match the RHEA reactions, with the definition of GO:0004058 broadened. See also http://www.ebi.ac.uk/intenz/query?cmd=SearchID&id=4522:

aromatic-L-amino-acid decarboxylase activity ; GO:0004058 Catalysis of the reaction: L-amino acid + H+ = R-H + CO2. EC:4.1.1.28 NB: Not the best, but R-H is most generic way I can think to describe the product.

5-hydroxy-L-tryptophan decarboxylase activity ; GO:NEW1 RHEA:18536 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin

L-dopa decarboxylase activity ; GO:NEW2 RHEA:12275
L-dopa + H+ = CO2 + dopamine synonym: DDC activity [PMID:19703902] synonym: 4-dihydroxyl-L-phenylalaine decarboxylase [PMID:19703902]

L-tryptophan decarboxylase activity ; GO:NEW3 RHEA:30342
L-tryptophan + H+ = CO2 + tryptamine

Thanks!

http://www.genome.jp/dbget-bin/www_bget?ec:4.1.1.28

Reported by: rebeccafoulger

Original Ticket: geneontology/ontology-requests/10995

[gocentral]

• assigned_to: RFoulger

Original comment by: jl242

[gocentral]

• status: open --> closed-accepted

Original comment by: rebeccafoulger

[gocentral]

Done. New terms are: 5-hydroxy-L-tryptophan decarboxylase activity ; GO:0036467 L-dopa decarboxylase activity ; GO:0036468 L-tryptophan decarboxylase activity ; GO:0036469

Original comment by: rebeccafoulger