7-methylguanosine RNA capping terms inconsistency

[gocentral]

GO:0009452 - 7-methylguanosine RNA capping (biological_process) [QuickGO, AmiGO, BioPortal]

Definition: "The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript." [PMID:9266685]

only refers to mRNA

but the hypermethylation term GO:0036261 - 7-methylguanosine cap hypermethylation (biological_process) [QuickGO, AmiGO, BioPortal]

Definition: "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation." [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984]

refers only to sn &sno does the hypermethylation only occur on sn and sno?

if so thats fine but maybe the def of GO:0009452 should be refined to remove the ref to polII as sno and sn RNA can be transcribed by other polymerases?

Reported by: ValWood

Original Ticket: geneontology/ontology-requests/11064

[gocentral]

It seems that cap methylation can occur on mRNA too? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825737/

Original comment by: ValWood

[gocentral]

• labels: --> Other term-related request
• assigned_to: Paola Roncaglia
• Group: None --> PomBase

Original comment by: paolaroncaglia

[gocentral]

Discussed at SF jamboree and resolved that Val will move her annotations to the child, while I will remove the string in italic from the def of GO:0009452: "is added to a nascent RNA polymerase II transcript".

Original comment by: paolaroncaglia

[gocentral]

Done.

Original comment by: paolaroncaglia

[gocentral]

• status: open --> closed-fixed

Original comment by: paolaroncaglia