Closed gocentral closed 9 years ago
Not necessarily -- pyrimidine dimers form between consecutive base residues on one strand, regardless of whether the other strand has the "correct" base.
Original comment by: mah11
Original comment by: ValWood
Of course...I'll take a closer look at the annotation instead.....
Original comment by: ValWood
... but I think those are repaired by the NER pathway... see http://en.wikipedia.org/wiki/Pyrimidine_dimer Which means there are two ways of annotating the same observation ?
Original comment by: pgaudet
That would make sense I think based on this http://www.pombase.org/spombe/result/SPBC19C7.09c#go I was trying to consolidate the annotation as it seems that we are describing the same process in multiple ways......
Original comment by: ValWood
OK got it so it looks as though this has a role in both UV-damage induced nucleotide excision repair (of pyrimidine dimers) and mismatch repair
If all pyrimidine dimers repaired by NER then maybe and it does have the exact synonym: exact pyrimidine-dimer repair, DNA damage excision
thenGO:0006289 and GO:0006290 pyrimidine dimer repair
should merge?
Original comment by: ValWood
Original comment by: ValWood
although there is also GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
the only other children are describing parts of the repair process (recognition, unwinding,removal, gap filling ) rather than other 'types' of repair
Original comment by: ValWood
Original comment by: ukemi
Not all pyrimidine dimers are repaired by nucleotide excision repair. There is also a type of repair called photoreactivation where an enzyme just cleaves the dimers. So this link shouldn't be made.
-D
Original comment by: ukemi
is defined "The repair of UV-induced T-T, C-T and C-C dimers." [ISBN:0815316194]
doesn't this make it is_a GO:0006298 - mismatch repair?
Reported by: ValWood
Original Ticket: geneontology/ontology-requests/11104