Question: difference between axon development and axonogenesis

[gocentral]

Hello,

What is the difference between GO:0061564 axon development (Def: The progession of an axon over time, from its initial formation to the mature structure.)

and GO:0007409 axonogenesis (Def: Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells.)

Can some use examples be added ? (please also not the typo in the definition of GO:0061564 axon development; "progession" should be "progression").

Thanks,

Pascale

Reported by: pgaudet

Original Ticket: geneontology/ontology-requests/11197

[gocentral]

Hi Pascale,

axon development covers both axonogenesis (de novo generation of an axon) and axon regeneration (regrowth after loss or damage, not necessarily of the whole axon). We could edit the defs as follows to clarify (including fixing typo):

axon development The progression of an axon over time, from its initial formation to the mature structure. Covers both axonogenesis (de novo generation of an axon) and axon regeneration (regrowth).

axonogenesis: De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. and add def. comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers axon regeneration (regrowth after loss or damage, not necessarily of the whole axon).

I think this should clear the confusion. Would you agree?

Thanks, Paola

Original comment by: paolaroncaglia

[gocentral]

• labels: --> Other term-related request, neurobiology
• assigned_to: Paola Roncaglia

Original comment by: paolaroncaglia

[gocentral]

Hi Paola,

Thanks for looking into this. I still think the definition for axon development is confusing: "axon development The progression of an axon over time, from its initial formation to the mature structure. Covers both axonogenesis (de novo generation of an axon) and axon regeneration (regrowth). "

The bit that mentions "from its initial formation to the mature structure" sounds exactly like axonogenesis. Can this be deleted ? would the definition still be information enough ?

Thanks, Pascale

Original comment by: pgaudet

[gocentral]

Hi Pascale,

That is the 'standard' bit for development terms, but in this case I think it could be safely removed, and have 'axon development' defined as "The progression of an axon over time. Covers both axonogenesis (de novo generation of an axon) and axon regeneration (regrowth)."

I'll check with David H. Then I'll do the edits next week.

Thanks, Paola

Original comment by: paolaroncaglia

[gocentral]

I think this plan is safe. Note also that axon development covers things that are not covered by axonogenesis, which refers to the morphogenesis or creation of shape or form of the developing axon. That is why fasciculation and its sib are children of the development term. They are part of the progression of the axon over time, but are not part of the creation of its shape or form.

Original comment by: ukemi

[gocentral]

Thanks. Settled on these updated defs:

axon development: The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).

axonogenesis: De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon. and added def. comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon).

Closing now, thanks,

Paola

Original comment by: paolaroncaglia

[gocentral]

• status: open --> closed-accepted

Original comment by: paolaroncaglia