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Source ontology files for the Gene Ontology
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NTR: glutamine amidotransferase II (GATase) complex #11470

Closed gocentral closed 9 years ago

gocentral commented 9 years ago

HI,

I'd like to request a new term for "glutamine amidotransferase II (GATase) complex", based on the paper pmid:22277648. The definition could be: "Enzyme complex that in S. cerevisiae has compnents Dug2/Dug3 and is able to catalyze the cleavage of glutathione into glutamate and Cys-Gly."

I can be assigned to "protein complex" as one of its children (is_a).

Thank you, Janos

Reported by: jdemetert

Original Ticket: geneontology/ontology-requests/11295

gocentral commented 9 years ago

Original comment by: ukemi

gocentral commented 9 years ago

http://amigo.geneontology.org/amigo/term/GO:0036374 http://enzyme.expasy.org/EC/3.4.19.13

Maybe this is it?

Original comment by: tberardini

gocentral commented 9 years ago

From the paper: "(Dug2p-Dug3p)2 is a GATaseII enzyme that cleaves the γ-glutamyl linkage of glutathione" - so, yes, that is the activity.

Janos

Original comment by: jdemetert

gocentral commented 9 years ago

Original comment by: ukemi

gocentral commented 9 years ago

[Term] +id: GO:0061672 +name: glutathione hydrolase complex +namespace: cellular_component +def: "Enzyme complex that in S. cerevisiae has compnents Dug2/Dug3 and is able to catalyze the cleavage of glutathione into glutamate and Cys-Gly." [GOC:dph] +synonym: "gamma-glutamyltranspeptidase complex" EXACT [GOC:dph] +synonym: "glutamine amidotransferase II complex" NARROW [PMID:22277648] +synonym: "glutathionase complex" EXACT [GOC:dph] +is_a: GO:0043234 ! protein complex +intersection_of: GO:0043234 ! protein complex +intersection_of: capable_of GO:0036374 ! glutathione hydrolase activity +created_by: dph +creation_date: 2014-11-24T14:38:08Z

Original comment by: ukemi