NTR: another kind of receptor clustering

[gocentral]

Hi,

I would like to annotate receptor clustering, specifically glutamatergic or glutamate (which ever name is preferred; I'm annotating from PMID:19723286), but we don't have a specific term for this, though we do go to this level of detail in other places in the ontology. So, I'd like to request a specific term for this. By comparison with the child terms of "neuron-neuron synaptic transmission - GO:0007270", it might also make sense to make the dopamine receptor clustering term too, though I don't need that one here.

neurotransmitter-gated ion channel clustering - GO:0072578

• gamma-aminobutyric acid recpetor clustering - GO:0097112
• glycine recpetor clustering - GO:0072579

  - glutamatergic receptor clustering - GO:new

neuron-neuron synaptic transmission - GO:0007270

• synaptic transmission, dopaminergic - GO:0001963
• synaptic transmission, GABAergic
• synaptic transmission, glutamatergic
• synaptic transmission, glycinergic

Karen

Reported by: krchristie

Original Ticket: geneontology/ontology-requests/11502

[gocentral]

• labels: --> New term request, neurobiology
• assigned_to: Paola Roncaglia

Original comment by: paolaroncaglia

[gocentral]

Hi Karen,

Here’s your new term:

[Term] +id: GO:0097688 +name: glutamate receptor clustering +namespace: biological_process +def: "The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane." [GOC:krc, PMID:19723286] +synonym: "glutamatergic receptor clustering" EXACT [] +is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering

For consistency with names of existing children of ‘neurotransmitter-gated ion channel clustering’, I named your term ‘glutamate receptor clustering’, and added ‘glutamatergic receptor clustering’ as a synonym.

I’ll leave the dopaminergic term aside for the moment until it’s actually needed for annotation - there are several others that we should add, on the same grounds… (see http://en.wikipedia.org/wiki/Neurotransmitter and http://en.wikipedia.org/wiki/Neurotransmitter_receptor#Example_neurotransmitter_receptors.5B14.5D)

Instead, I have placed the existing GO:0097113 (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering) as is_a GO:0097688 glutamate receptor clustering, and edited its def. accordingly.

Thanks,

Paola

Original comment by: paolaroncaglia

[gocentral]

• status: open --> closed-accepted

Original comment by: paolaroncaglia