costamere

[gocentral]

I need (maybe) to add a new term to component:

costamere: def: vinculin-containing myofibril attachment site, connects Z discs to the sarcolemma (condensed def from the Oxford).

I'm not exactly sure if this would be considered a part of the Z disc. (GO:0030018), or of the sarcomere. Any expert opinions would be welcome:

Additional info from Dictionary of Cell & Molecular Biology: regular periodic submembranous array of vinculin in muscle cell; links sarcomeres to the membrane and is associated with links to extracellular matrix.

Although the term is mentioned in the paper I'm curating, it is interesting that this term does not appear in recent books such as Lodish et al Mol Cell Biol (2000) or Alberts et al.

Other info I dug up:

Costameres are ribs of protein that contain vinculin and lie between the cell membrane and the Z line in some skeletal muscles and in cardiac muscle (Craig and Pardo, 1983; Pardoet al., 1983). Costameres encircle the myofibril and offer a contact point to couple contractions of the myofibril to the extracellular matrix along the length of muscle cells (Shear andBloch, 1985).

Costamere Protein complex consisting of cytoskeleton, transmembrane glycoproteins, and extracellular matrix that is at the level of Z bands involved in transferring tension from contractile elements to connective tissue and may serve as a mechanosensor for signal transduction

Many gene mutations that cause DCM in humans
seem to affect cytoskeletal proteins forming the costamere

Dystrophin is a costameric protein

Reported by: hdrabkin

Original Ticket: "geneontology/ontology-requests/1179":https://sourceforge.net/p/geneontology/ontology-requests/1179

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Incyte have also requested this same term - seems okay to me.

Original comment by: jl242

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• milestone: --> TermGenie
• assigned_to: nobody --> jl242

Original comment by: jl242

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If I could get an opinion as to sarcomere/z-disc location, I could put it in. Part of the sarcomere might be safe for now.

Original comment by: hdrabkin

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Incyte have it as part of the Z-disc with def:

The peripheral part of the Z-disk, which connects the sarcomeres to the sarcolemma.

?

Original comment by: jl242

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We've had some muscle experts in today (happy coincidence!), and I'm reliably informed that the costamere is part of niether the z-disc or the sarcomere - it needs to go directly under 'myofibril ; GO:0030016'.

I can go ahead and add this when I hear from you, as I've got this same term request from someone else too.

Original comment by: jl242

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Great, go ahead if you'd like then. I did some additional reading but STILL failed to find something that pinned it down.

Original comment by: hdrabkin

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• status: open --> closed

Original comment by: jl242

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That's why I took the opportunity to pick the brains of a handy expert ;)

Added 'costamere ; GO:0043034' as a child of 'myofibril ; GO:0030016'.

Original comment by: jl242

[gocentral]

• status: closed --> closed-accepted

Original comment by: jl242