translation factors

[gocentral]

An old-ish one from Lisa Matthews:

Hi Midori, I have a true path question related to the term :translation factor

translation factor

nucleic acid binding molecular_function

I have run across several instance of translation factors that are not necessarily DNA binding and was wondering if any thought had been given to revising the part of the hierarchy to accommodate situations like this? Thanks! Lisa

Reported by: mah11

Original Ticket: "geneontology/ontology-requests/118":https://sourceforge.net/p/geneontology/ontology-requests/118

[gocentral]

Logged In: YES user_id=436423

found another relevant email from Lisa:

Here are some examples:

MNPEP

The protein is actually a positive translation regulator that is associated with eIF2a and prevents kinase-mediated phosphorylation of eIF2a. Since the protein functions through interaction with eIF2a perhaps it should have a MF GO term of "translation co-factor", "translation regulator", "translation activator", or "initiation factor associated protein" etc. as part of an ontology that doesn't include nucleic acid binding so the true path rule will be operative

a similar example: yeast GCD7 protein is an eIF2B subunit(GTP-GDP exchange factor) which functions in translation initiation.

Original comment by: mah11

[gocentral]

• labels: --> Other term-related request

Original comment by: mah11

[gocentral]

• assigned_to: nobody --> girlwithglasses

Original comment by: nobody

[gocentral]

Logged In: YES user_id=473796

Created a new term, translation regulator (45182), to cover all translation factor terms [this mirrors the sister term, transcription regulator]. Renamed "translation factor" to "translation factor, nucleic acid binding", and created a new term "translation factor, non nucleic acid binding" (45183) to cover instances of substances involved in translation which do not bind to nucleic acids. At present this term has no children, so please request any child terms you need.

Original comment by: nobody

[gocentral]

• status: open --> closed-fixed

Original comment by: nobody