Edits to: BAT3 complex ; GO:0071818

[gocentral]

I'm annotating proteins that are components of, or bind to, the BAG6-UBL4A-TRC35 complex. This is the same as the BAT3 complex:

BAT3 complex ; GO:0071818 An ER membrane insertion complex that acts by facilitating tail-anchored protein capture by ASNA1/TRC40. In mammals the complex contains Bat3, TRC35 and Ubl4A. is_a: ER membrane insertion complex ; GO:0072379

I'd like to add synonyms and revise the definition and parentage to make it clearer that it's the same trimeric complex.

1. New synonyms for BAT3 complex ; GO:0071818:

exact: BAG6-UBL4A-TRC35 complex [PMID:21636303] exact: Bag6 complex [PMID:21636303] exact: Bat3-TRC35-Ubl4A complex [PMID:20676083]

1. Revised definition to reflect it's role in ERAD regulation (see PMID:21636303).

E.g: A multi-protein complex containing, in mammals, BAT3 (BAG6) and its cofactors TRC35 (GET4) and UBL4A. Facilitates tail-anchored protein capture by ASNA1/TRC4 and also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD).

1. Parentage (not sure of best way to do this): Could add: capable_of_part_of: chaperone-mediated protein transport ; GO:0072321 or: capable_of_part_of: positive regulation of ER-associated ubiquitin-dependent protein catabolic process ; GO:1903071 capable_of_part_of: protein insertion into membrane ; GO:0051205

Remove: 'ER membrane insertion complex ; GO:0072379' parentage because the complex can have other roles.

1. Also need a 'BAT3 complex binding GO:NEW' term (PMID:21636303).

Thank you!

Reported by: rebeccafoulger

Original Ticket: geneontology/ontology-requests/11657

[gocentral]

• assigned_to: David Osumi-Sutherland

Original comment by: dosumis

[gocentral]

Remove: 'ER membrane insertion complex ; GO:0072379' parentage because the complex can have other roles.

Strictly, this is allowed if it is one of the roles. Using capable_of and capable_of_part_of just say that the complex is capable of executing an MF, BP (or BP part) given the right circumstances and that this happens as part of normal biology.

This is different from applying part_of, which must be true at all times in order to be in the ontology.

Original comment by: dosumis

[gocentral]

Made changes to BAT3 complex as requested, but classification under ER membrane insertion complex remains. It is now inferred via 'capable of part of' some 'tail-anchored membrane protein insertion into ER membrane'.

Original comment by: dosumis

[gocentral]

• assigned_to: David Osumi-Sutherland --> RFoulger

Original comment by: rebeccafoulger

[gocentral]

Added synonyms to BAT3 complex. Will test out new TG template to add in the complex binding term when the synonyms filter through.

Original comment by: rebeccafoulger

[gocentral]

• status: open --> closed-accepted

Original comment by: rebeccafoulger

[gocentral]

Added in TG: BAT3 complex binding ; GO:1904288

Original comment by: rebeccafoulger