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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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"donor selection" ancestry #11872

Closed gocentral closed 9 years ago

gocentral commented 9 years ago

I am not convinced that the “donor selection” part of mating-type switching is a DNA metabolic process (it seems to be an chromatin accessibility issue), in which case DNA metabolic process should only be an ancestor of the “GO:0007534 gene conversion at mating-type locus” term, and not the entire mating-type switching process

Reported by: ValWood

Original Ticket: geneontology/ontology-requests/11710

gocentral commented 9 years ago

There's no is_a path back to DNA metabolic process, so there is no inference that "the “donor selection” part of mating-type switching is a DNA metabolic process."

If 'mating type switching' itself is not a 'DNA metabolic process', then I can remove that. From a quick review, it looks like it would be sufficient for these children to be classified as types of 'DNA metabolic process':

'gene conversion at mating-type locus, DNA double-strand break formation' 'gene conversion at mating-type locus, DNA double-strand break processing' 'gene conversion at mating-type locus, DNA repair synthesis' 'gene conversion at mating-type locus, termination of copy-synthesis' (?)

Do you agree?

Cheers, David

Original comment by: dosumis

gocentral commented 9 years ago

Diff:


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 I am not convinced that the “donor selection” part of mating-type switching is a DNA metabolic process (it seems to be an chromatin accessibility issue), in which case DNA metabolic process should only be an ancestor of the “GO:0007534 gene conversion at mating-type locus” term, and not the entire mating-type switching process

Original comment by: dosumis

gocentral commented 9 years ago

yep, I think only the donor selection part isn't. it seems to be via chromatin remodelling, where DNA isn't metabolised....

Original comment by: ValWood

gocentral commented 9 years ago

Diff:


--- old
+++ new
@@ -1,3 +1,2 @@
-
 I am not convinced that the “donor selection” part of mating-type switching is a DNA metabolic process (it seems to be an chromatin accessibility issue), in which case DNA metabolic process should only be an ancestor of the “GO:0007534 gene conversion at mating-type locus” term, and not the entire mating-type switching process

Original comment by: dosumis