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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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NTR: (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity #12300

Closed robnash closed 8 years ago

robnash commented 8 years ago

Hi,

The following paper describes a novel transhydrogenase activity in yeast:

Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase. PMID: 26774271

I therefore would like to request the following term:

Term: (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity

Definition: Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor

Synonyms: D-2HG-pyruvate transhydrogenase activity, R-2-hydroxyglutarate alpha-pyruvate transhydrogenase activity

Instance of GO:0016614 oxidoreductase activity, acting on CH-OH group of donors

Definition reference: PMID: 26774271

Thanks, Rob

dosumis commented 8 years ago

Hi Rob,

Looks straightforward. I'd like to add an EC number if poss. Do you know if there is one?

Cheers, David

dosumis commented 8 years ago

Added as requested. No changes. Cheers, David

ValWood commented 8 years ago

Is there an EC number for this yet? Oliver lab interested for metabolic map....

robnash commented 8 years ago

Thanks for adding this David. Much appreciated.

I looked around on the ExPASy site and see nothing that matches this activity. According to the paper this is a new enzymatic activity so I don't think it will have a number. If someone knows where to request an EC number I can forward what I have.

Cheers, Rob