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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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NTR: ferroptosis #12321

Closed paolaroncaglia closed 8 years ago

paolaroncaglia commented 8 years ago

For the records. Stemming from review of the latest recommendations from the Nomenclature Committee on Cell Death (PMID: 25236395), I will add a new term as below:

name: ferroptosis is_a: programmed cell death def: A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes. dbxrefs: GOC:mtg_apoptosis, PMID: 25236395, PMID: 26794443 synonym: iron-dependent programmed cell death (related)

paolaroncaglia commented 8 years ago

Added GO:0097707 ferroptosis