casein kinase obsoletions?

[gocentral]

casein kinase I activity GO:0004681 protein kinase CK2 activity GO:0004682 look like gene products

both EC 2.3.1.37

Reported by: ValWood

Original Ticket: "geneontology/ontology-requests/1257":https://sourceforge.net/p/geneontology/ontology-requests/1257

[gocentral]

• labels: --> Other term-related request
• assigned_to: nobody --> girlwithglasses
• milestone: --> 224410

Original comment by: jl242

[gocentral]

Logged In: NO

Casein Kinase 1 and 2 (CK1 and CK2) are not single genes, but rather very distinct families of protein kinases, named after their affinity for casein, an experimentally tractible but biologically irrelevant substrate. Current usage retains the abbreviations CK1 and CK2 (note arabic numerals), with an attempt to rename as "Cell Kinase", due to their wide substrate range.

The human genome has 7 CK1 genes and two CK2 genes, and both families are also found in various yeast species, worm and fly, indicating distinct, evolutionary conseved functions for each. Distinct, conserved roles within each family are not yet fully clear, but the literature does show very distinct functions for individual members, and little commonality between CK1 and CK2 genes other than their broad in vitro substrate specificity (hence, historically, they were among the first kinases to be isolated, using casein as a substrate).

The original comment lists both as having EC 2.3.1.37, but this is incorrect (that entry stands for 5-Aminolevulinate synthase)

Original comment by: nobody

[gocentral]

Logged In: YES user_id=914063

<That last comment was by Gerard Manning (gerard- manning@ceolas.org>. For some reason, though I was logged in to SourceForge, it didn't annotate the comment as from me.

Original comment by: ceolas

[gocentral]

Logged In: YES user_id=516865

thanks that helps...there is protein kinase CK2, intrinsic regulator activity as a child of protein kinase CK2 activity GO:0004682 so that proably needs moving to enzyme regulator so it doesn't get the kinase activity parentage

Original comment by: ValWood

[gocentral]

• assigned_to: girlwithglasses --> nobody

Original comment by: girlwithglasses

[gocentral]

Logged In: YES user_id=451873

EC has both of these enzymes listed as 2.7.1.37 - so although both classes are from very different protein families, I think they may well be the same function. Unless they have different substates? But I couldn't find a way to write a (functional) definition for CK1, such that it differs from CK2.

I've changed the name of casein kinase I activity GO:0004681 to protein kinase CK1 activity for consistency for now anyway. Oh and the intrinsic regulator activity term is now obsolete.

Original comment by: jl242

[gocentral]

Logged In: YES user_id=516865

Can this be closed?

val

Original comment by: ValWood

[gocentral]

Logged In: YES user_id=436423

not sure it's been resolved completely, but I'm willing to close it

Original comment by: mah11

[gocentral]

• status: open --> closed-later

Original comment by: mah11

[gocentral]

• milestone: 224410 --> PomBase

Original comment by: mah11