geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
Creative Commons Attribution 4.0 International
220 stars 40 forks source link

definition of GO:0071704 organic substance metabolic process #12973

Closed deustp01 closed 7 years ago

deustp01 commented 7 years ago

It's now "the chemical reactions and pathways involving an organic substance, any molecular entity containing carbon" which would appear to include classic intermediary metabolism, which it does, as is_a children, but also metabolism of carbon-containing macromolecules like proteins, RNA, and DNA, which it does not. That distinction seems fine, so could something be added to the organic substance definition to make it explicit, something like Michael Ashburner's distinction between directly or indirectly encoded molecules and unencoded ones. That may not exactly conform to ChEBI, but neither does a silent decision to treat RNA, DNA, and proteins as not containing carbon atoms. If a revised definition would break things, could a comment be added?

tberardini commented 7 years ago

@deustp01 : DNA, RNA, and protein metabolism trace their parentage to 'organic substance metabolic process'. Where's the missing link?

screen shot 2017-01-30 at 3 06 54 pm screen shot 2017-01-30 at 3 06 29 pm screen shot 2017-01-30 at 3 07 41 pm