slight rejig of "mitotic chromosome movement towards spindle pole" and ntr

ValWood commented 7 years ago

GO:0007079 mitotic chromosome movement towards spindle pole Def:The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.

but mitotic chromosomses also move towards the spindle pole during chromosome recapture (when chromsomes become detached from the spindle pole body (also called "kinetochore loss")

So this should be renamed mitotic chromosome movement towards spindle pole after chromosome separation

GO:1990942 mitotic metaphase chromosome recapture Is also an instance of "mitotic chromosome movement towards spindle pole"

So we could have a term "mitotic chromosome movement towards spindle pole" which is a parent of both?

This might be useful because these processes probably use different kinesin etc, and also it would help curators to select the correct term, as this can be a bit confusing if you aren't familiar with it.

This is a nice cartoon: cartoon

from PMID:27146110 nice paper, can be used for refs but there are lost of others...

Any beautifully curated by the author too: https://curation.pombase.org/pombe/curs/ffbebba84aad52e5/ro

hdrabkin commented 7 years ago

Could you supply a def to your requested term that differentiates it from mitotic chromosome movement towards spindle pole/ to be :mitotic chromosome movement towards spindle pole after chromosome separation Def:The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis. Thanks hd

ValWood commented 7 years ago

See above.

There are 2 types of "chromosome movement towards the spindle pole" that occur during chromosome segregation.

One type occurs before chromosome separation, when kinetochores/chromosomes become unattached and need to be recaptured and "reeled in" (see fig above). This occurs before biorientation

The second type mitotic chromosome movement towards spindle pole after chromosome separation

is the moving apart of chromosmes after separation (i.e after cohesin is cleaved)

The above ref can be used because it shows a figure which differentiates the 2 clearly

ValWood commented 7 years ago

Ah sorry, I didn't include the ref: PMID:27146110 but there are many....

ValWood commented 7 years ago

Hi Harold,

Did you have any outstanding questions here? Seems straightforward (small rejig). Let me know if it isn't clear...can Skype.

Thanks

Val

hdrabkin commented 7 years ago

Coming back to this: so it seems to me that the definition of the term you request for a name change needs to have "after chromosome separation" added to it also? And how will this effect all existing annotations.

NTR:mitotic chromosome movement towards spindle pole -----GO:1990942 mitotic metaphase chromosome recapture -----GO:0007079 mitotic chromosome movement towards spindle pole/mitotic chromosome movement towards spindle pole after chromosome separation

NTR def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. BUT THIS MEANS changed name term needs the definition changed also?

ValWood commented 7 years ago

This term NTR:mitotic chromosome movement towards spindle pole is not always after chromosome separation. "chromosome recapture" is a type of chromosome to spindle pole movement that occurs BEFORE chromosome separation. It's a mechanism to correct problems when chromosomes are become detached from the SPB before biorientation.

v

ValWood commented 4 years ago

removed @vanaukenk and added @hdrabkin as assignee as @hdrabkin seemed to be working on this last.

@hdrabkin please let me know if anything here isn't clear. I will try again!

hdrabkin commented 4 years ago

Please: List the exact def you want here:

pgaudet commented 2 years ago

ping @ValWood

ValWood commented 2 years ago

Let's review this as part of my training (or can be one of, my projects) after the funding comes through....no time right now.

ValWood commented 2 years ago

@manulera

(this ticket might not be required)

manulera commented 1 year ago

I agree with @ValWood that these two processes serve different functions, but it makes sense to have a common parent term. Specifically in PMID:27146110 the mechanism driving mitotic metaphase chromosome recapture and mitotic chromosome movement towards ... are the same.

Simply put, when chromatid pairs are biattached, the kinetochore microtubules pull on them from both spindle poles, which creates tension on the attachment and makes it stable (this is a unique property of kinetochore attachments, in which tension increases the strength of the bond).

In addition to the effect on the attachment, tension prevents microtubule catastrophe (prevents microtubules from switching from growth to shrinkage). Microtubule catastrophe is also length-dependent thanks to kinesin-8 (longer microtubules are more likely to switch from growht to shrinkage).

So we have three scenarios:

The "floating chromatid pair" in the first frame of the figure: when a microtubule attaches to the kinetochore, there is an attachment without tension, so the microtubules tend to shrink and reel-in the chromosome towards the pole.
The "double attached chromatid pair" in frame 5, in which biattachment creates tension, stabilising the attachment and preventing kinetochore microtubule shrinkage. Because microtubule catastrophe is length-dependent, an equilibrium length can be stablished in which the growth-promoting effect of tension from the attachment matches the shrinkage-promoting effect of microtubule length. This promotes equal lengths of kinetochore microtubules on both spindle halves and drives the chromosomes to the center of the spindle (there is of course some oscillations).
The "post cohesin cleavage single chromatids": Because cohesin is cleaved, there is no longer tension applied on the microtubules, which then simply shrink, dragging the kinetochores and the chromosomes to the spindle pole.

So the mechanisms driving the movement can be the same, although I am sure there is diversity of mechanisms, for example in animal cells there is also depolymerisation of microtubules at their minus ends that is different before and after cohesin cleavage, if I remember correctly.

manulera commented 1 year ago

These are the current relationships

graph BT;
      http://purl.obolibrary.org/obo/GO_0051303["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051303>GO:0051303</a><br>establishment of chr<br>omosome localization<br>"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051649["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051649>GO:0051649</a><br>establishment of loc<br>alization in cell"];
      http://purl.obolibrary.org/obo/GO_0051303["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051303>GO:0051303</a><br>establishment of chr<br>omosome localization<br>"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051656["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051656>GO:0051656</a><br>establishment of org<br>anelle localization"];
      http://purl.obolibrary.org/obo/GO_0051303["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051303>GO:0051303</a><br>establishment of chr<br>omosome localization<br>"]-->|is_a|http://purl.obolibrary.org/obo/GO_0050000["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0050000>GO:0050000</a><br>chromosome localizat<br>ion"];
      http://purl.obolibrary.org/obo/GO_0051649["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051649>GO:0051649</a><br>establishment of loc<br>alization in cell"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051234["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051234>GO:0051234</a><br>establishment of loc<br>alization"];
      http://purl.obolibrary.org/obo/GO_0051649["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051649>GO:0051649</a><br>establishment of loc<br>alization in cell"]-->|part_of|http://purl.obolibrary.org/obo/GO_0051641["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051641>GO:0051641</a><br>cellular localizatio<br>n"];
      http://purl.obolibrary.org/obo/GO_0051234["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051234>GO:0051234</a><br>establishment of loc<br>alization"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051179["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051179>GO:0051179</a><br>localization"];
      http://purl.obolibrary.org/obo/GO_0051641["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051641>GO:0051641</a><br>cellular localizatio<br>n"]-->|is_a|http://purl.obolibrary.org/obo/GO_0009987["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0009987>GO:0009987</a><br>cellular process"];
      http://purl.obolibrary.org/obo/GO_0051641["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051641>GO:0051641</a><br>cellular localizatio<br>n"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051179["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051179>GO:0051179</a><br>localization"];
      http://purl.obolibrary.org/obo/GO_0051656["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051656>GO:0051656</a><br>establishment of org<br>anelle localization"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051234["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051234>GO:0051234</a><br>establishment of loc<br>alization"];
      http://purl.obolibrary.org/obo/GO_0051656["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051656>GO:0051656</a><br>establishment of org<br>anelle localization"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051640["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051640>GO:0051640</a><br>organelle localizati<br>on"];
      http://purl.obolibrary.org/obo/GO_0007080["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007080>GO:0007080</a><br>mitotic metaphase pl<br>ate congression"]-->|is_a|http://purl.obolibrary.org/obo/GO_1903047["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:1903047>GO:1903047</a><br>mitotic cell cycle p<br>rocess"];
      http://purl.obolibrary.org/obo/GO_0007080["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007080>GO:0007080</a><br>mitotic metaphase pl<br>ate congression"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051310["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051310>GO:0051310</a><br>metaphase plate cong<br>ression"];
      http://purl.obolibrary.org/obo/GO_0007080["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007080>GO:0007080</a><br>mitotic metaphase pl<br>ate congression"]-->|part_of|http://purl.obolibrary.org/obo/GO_0000070["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000070>GO:0000070</a><br>mitotic sister chrom<br>atid segregation"];
      http://purl.obolibrary.org/obo/GO_0051310["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051310>GO:0051310</a><br>metaphase plate cong<br>ression"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051303["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051303>GO:0051303</a><br>establishment of chr<br>omosome localization<br>"];
      http://purl.obolibrary.org/obo/GO_0051310["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051310>GO:0051310</a><br>metaphase plate cong<br>ression"]-->|part_of|http://purl.obolibrary.org/obo/GO_0098813["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0098813>GO:0098813</a><br>nuclear chromosome s<br>egregation"];
      http://purl.obolibrary.org/obo/GO_1990942["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:1990942>GO:1990942</a><br>mitotic metaphase ch<br>romosome recapture</strong></u>"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051303["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051303>GO:0051303</a><br>establishment of chr<br>omosome localization<br>"];
      http://purl.obolibrary.org/obo/GO_1990942["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:1990942>GO:1990942</a><br>mitotic metaphase ch<br>romosome recapture</strong></u>"]-->|part_of|http://purl.obolibrary.org/obo/GO_0007080["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007080>GO:0007080</a><br>mitotic metaphase pl<br>ate congression"];
      http://purl.obolibrary.org/obo/GO_1903047["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:1903047>GO:1903047</a><br>mitotic cell cycle p<br>rocess"]-->|is_a|http://purl.obolibrary.org/obo/GO_0022402["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0022402>GO:0022402</a><br>cell cycle process"];
      http://purl.obolibrary.org/obo/GO_1903047["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:1903047>GO:1903047</a><br>mitotic cell cycle p<br>rocess"]-->|part_of|http://purl.obolibrary.org/obo/GO_0000278["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000278>GO:0000278</a><br>mitotic cell cycle"];
      http://purl.obolibrary.org/obo/GO_0022402["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0022402>GO:0022402</a><br>cell cycle process"]-->|is_a|http://purl.obolibrary.org/obo/GO_0009987["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0009987>GO:0009987</a><br>cellular process"];
      http://purl.obolibrary.org/obo/GO_0022402["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0022402>GO:0022402</a><br>cell cycle process"]-->|part_of|http://purl.obolibrary.org/obo/GO_0007049["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007049>GO:0007049</a><br>cell cycle"];
      http://purl.obolibrary.org/obo/GO_0009987["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0009987>GO:0009987</a><br>cellular process"]-->|is_a|http://purl.obolibrary.org/obo/GO_0008150["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0008150>GO:0008150</a><br>biological_process"];
      http://purl.obolibrary.org/obo/GO_0007049["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007049>GO:0007049</a><br>cell cycle"]-->|is_a|http://purl.obolibrary.org/obo/GO_0009987["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0009987>GO:0009987</a><br>cellular process"];
      http://purl.obolibrary.org/obo/GO_0000278["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000278>GO:0000278</a><br>mitotic cell cycle"]-->|is_a|http://purl.obolibrary.org/obo/GO_0007049["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007049>GO:0007049</a><br>cell cycle"];
      http://purl.obolibrary.org/obo/GO_0000278["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000278>GO:0000278</a><br>mitotic cell cycle"]-->|has_part|http://purl.obolibrary.org/obo/GO_0140014["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140014>GO:0140014</a><br>mitotic nuclear divi<br>sion"];
      http://purl.obolibrary.org/obo/GO_0140014["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140014>GO:0140014</a><br>mitotic nuclear divi<br>sion"]-->|is_a|http://purl.obolibrary.org/obo/GO_0000280["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000280>GO:0000280</a><br>nuclear division"];
      http://purl.obolibrary.org/obo/GO_0140014["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140014>GO:0140014</a><br>mitotic nuclear divi<br>sion"]-->|is_a|http://purl.obolibrary.org/obo/GO_1903047["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:1903047>GO:1903047</a><br>mitotic cell cycle p<br>rocess"];
      http://purl.obolibrary.org/obo/GO_0000280["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000280>GO:0000280</a><br>nuclear division"]-->|is_a|http://purl.obolibrary.org/obo/GO_0048285["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0048285>GO:0048285</a><br>organelle fission"];
      http://purl.obolibrary.org/obo/GO_0048285["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0048285>GO:0048285</a><br>organelle fission"]-->|is_a|http://purl.obolibrary.org/obo/GO_0006996["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0006996>GO:0006996</a><br>organelle organizati<br>on"];
      http://purl.obolibrary.org/obo/GO_0006996["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0006996>GO:0006996</a><br>organelle organizati<br>on"]-->|is_a|http://purl.obolibrary.org/obo/GO_0016043["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0016043>GO:0016043</a><br>cellular component o<br>rganization"];
      http://purl.obolibrary.org/obo/GO_0016043["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0016043>GO:0016043</a><br>cellular component o<br>rganization"]-->|is_a|http://purl.obolibrary.org/obo/GO_0071840["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0071840>GO:0071840</a><br>cellular component o<br>rganization or bioge<br>nesis"];
      http://purl.obolibrary.org/obo/GO_0071840["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0071840>GO:0071840</a><br>cellular component o<br>rganization or bioge<br>nesis"]-->|is_a|http://purl.obolibrary.org/obo/GO_0009987["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0009987>GO:0009987</a><br>cellular process"];
      http://purl.obolibrary.org/obo/GO_0051305["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051305>GO:0051305</a><br>chromosome movement <br>towards spindle pole<br>"]-->|is_a|http://purl.obolibrary.org/obo/GO_0007018["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007018>GO:0007018</a><br>microtubule-based mo<br>vement"];
      http://purl.obolibrary.org/obo/GO_0051305["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051305>GO:0051305</a><br>chromosome movement <br>towards spindle pole<br>"]-->|is_a|http://purl.obolibrary.org/obo/GO_0022402["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0022402>GO:0022402</a><br>cell cycle process"];
      http://purl.obolibrary.org/obo/GO_0051305["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051305>GO:0051305</a><br>chromosome movement <br>towards spindle pole<br>"]-->|is_a|http://purl.obolibrary.org/obo/GO_0050000["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0050000>GO:0050000</a><br>chromosome localizat<br>ion"];
      http://purl.obolibrary.org/obo/GO_0051305["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051305>GO:0051305</a><br>chromosome movement <br>towards spindle pole<br>"]-->|part_of|http://purl.obolibrary.org/obo/GO_0098813["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0098813>GO:0098813</a><br>nuclear chromosome s<br>egregation"];
      http://purl.obolibrary.org/obo/GO_0007018["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007018>GO:0007018</a><br>microtubule-based mo<br>vement"]-->|is_a|http://purl.obolibrary.org/obo/GO_0007017["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007017>GO:0007017</a><br>microtubule-based pr<br>ocess"];
      http://purl.obolibrary.org/obo/GO_0007017["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007017>GO:0007017</a><br>microtubule-based pr<br>ocess"]-->|is_a|http://purl.obolibrary.org/obo/GO_0009987["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0009987>GO:0009987</a><br>cellular process"];
      http://purl.obolibrary.org/obo/GO_0050000["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0050000>GO:0050000</a><br>chromosome localizat<br>ion"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051640["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051640>GO:0051640</a><br>organelle localizati<br>on"];
      http://purl.obolibrary.org/obo/GO_0051640["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051640>GO:0051640</a><br>organelle localizati<br>on"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051179["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051179>GO:0051179</a><br>localization"];
      http://purl.obolibrary.org/obo/GO_0051179["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051179>GO:0051179</a><br>localization"]-->|is_a|http://purl.obolibrary.org/obo/GO_0008150["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0008150>GO:0008150</a><br>biological_process"];
      http://purl.obolibrary.org/obo/GO_0098813["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0098813>GO:0098813</a><br>nuclear chromosome s<br>egregation"]-->|is_a|http://purl.obolibrary.org/obo/GO_0007059["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007059>GO:0007059</a><br>chromosome segregati<br>on"];
      http://purl.obolibrary.org/obo/GO_0007059["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007059>GO:0007059</a><br>chromosome segregati<br>on"]-->|is_a|http://purl.obolibrary.org/obo/GO_0022402["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0022402>GO:0022402</a><br>cell cycle process"];
      http://purl.obolibrary.org/obo/GO_0000070["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000070>GO:0000070</a><br>mitotic sister chrom<br>atid segregation"]-->|is_a|http://purl.obolibrary.org/obo/GO_1903047["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:1903047>GO:1903047</a><br>mitotic cell cycle p<br>rocess"];
      http://purl.obolibrary.org/obo/GO_0000070["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000070>GO:0000070</a><br>mitotic sister chrom<br>atid segregation"]-->|is_a|http://purl.obolibrary.org/obo/GO_0000819["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000819>GO:0000819</a><br>sister chromatid seg<br>regation"];
      http://purl.obolibrary.org/obo/GO_0000070["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000070>GO:0000070</a><br>mitotic sister chrom<br>atid segregation"]-->|part_of|http://purl.obolibrary.org/obo/GO_0140014["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140014>GO:0140014</a><br>mitotic nuclear divi<br>sion"];
      http://purl.obolibrary.org/obo/GO_0000819["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000819>GO:0000819</a><br>sister chromatid seg<br>regation"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051276["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051276>GO:0051276</a><br>chromosome organizat<br>ion"];
      http://purl.obolibrary.org/obo/GO_0000819["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000819>GO:0000819</a><br>sister chromatid seg<br>regation"]-->|is_a|http://purl.obolibrary.org/obo/GO_0098813["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0098813>GO:0098813</a><br>nuclear chromosome s<br>egregation"];
      http://purl.obolibrary.org/obo/GO_0051276["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051276>GO:0051276</a><br>chromosome organizat<br>ion"]-->|is_a|http://purl.obolibrary.org/obo/GO_0006996["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0006996>GO:0006996</a><br>organelle organizati<br>on"];
      http://purl.obolibrary.org/obo/GO_0007079["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007079>GO:0007079</a><br>mitotic chromosome m<br>ovement towards spin<br>dle pole</strong></u>"]-->|is_a|http://purl.obolibrary.org/obo/GO_1903047["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:1903047>GO:1903047</a><br>mitotic cell cycle p<br>rocess"];
      http://purl.obolibrary.org/obo/GO_0007079["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007079>GO:0007079</a><br>mitotic chromosome m<br>ovement towards spin<br>dle pole</strong></u>"]-->|is_a|http://purl.obolibrary.org/obo/GO_0051305["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0051305>GO:0051305</a><br>chromosome movement <br>towards spindle pole<br>"];
      http://purl.obolibrary.org/obo/GO_0007079["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:0007079>GO:0007079</a><br>mitotic chromosome m<br>ovement towards spin<br>dle pole</strong></u>"]-->|part_of|http://purl.obolibrary.org/obo/GO_0000070["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0000070>GO:0000070</a><br>mitotic sister chrom<br>atid segregation"];

geneontology / go-ontology

slight rejig of "mitotic chromosome movement towards spindle pole" and ntr #13542