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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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NTR: microglial cell (CL:0000129) activation (and maybe: glial cell (CL:0000243) activation) #13642

Closed BarbaraCzub closed 7 years ago

BarbaraCzub commented 7 years ago

Hello,

I am annotating PMID: 18723082, which demonstrates activation of astrocytes as well as microglial cells in response to amyloid-beta. https://www.ncbi.nlm.nih.gov/pubmed/18723082

We currently have the GO term: 'GO:0048143 astrocyte activation' https://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0048143 However, there appears to be no term for 'microglial cell activation'.

In the CL ontology 'CL:0000129 microglial cell' and 'CL:0000127 astrocyte' are both descendants of 'CL:0000243 glial cell (sensu Vertebrata)'. So in GO, the new term 'microglial cell activation' could be positioned as a child of 'GO:0001775 cell activation' (as is currently the case for 'GO:0048143 astrocyte activation'), or an additional term 'glial cell (CL:0000243) activation' can be included as a child of 'GO:0001775 cell activation', and a parent of both' GO:0048143 astrocyte activation' and NEW GO term 'microglial cell activation'.

'GO:0001775 cell activation'

NEW GO term 'glial cell (CL:0000243) activation'

'GO:0048143 astrocyte activation' NEW GO term 'microglial cell (CL:0000129) activation'

This issue is loosely related to a previous NTR #13574.

DbxRef: ARUK-UCL and GOC:bc.

Thanks, Barbara

ukemi commented 7 years ago

Hi Barbara,

We already have microglial cell activation GO:0001774. I have added glial cell activation. Both the astrocyte and the microglial terms are correctly classified under this.

BarbaraCzub commented 7 years ago

Thanks @ukemi Not sure how I missed this.