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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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Protein crotonylation and protein butyrylation #13937

Closed sylvainpoux closed 7 years ago

sylvainpoux commented 7 years ago

Hi, I would need a series of terms for a number of protein acyltransferase activities. It looks like protein acetylation is not the only protein acylation and that other acylation modifications are present on lysines

I have a mixed feeling concerning creating specific terms for histones. We did that in the past, but on the other hand, histones are proteins and most enzymes have non-histone substrates

Thanks

Sylvain

1)

Name: Protein crotonyltransferase activity Category: Function Definition: Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide. Child of GO:0016410 N-acyltransferase activity PMID:25818647

2) Name: Protein butyryltransferase activity Category: Function Definition: Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide. Child of GO:0016410 N-acyltransferase activity PMID:27105113

3) Name: peptidyl-lysine crotonylation Category: Process Definition: The crotonylation of peptidyl-lysine. child of GO:0043543 protein acylation PMID:25818647

4) Name: peptidyl-lysine butyrylation Category: Process Definition: The butyrylation of peptidyl-lysine. child of GO:0043543 protein acylation PMID:27105113

We migh also create specific terms for histone crotonyltransferase activity and histone butyryltransferase activity, but I am unsure that we should systematically create specific terms for histone modifications since in most cases, enzymes also modify non-histone proteins

5) Name: histone crotonyltransferase activity Definition: Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone. child of Protein crotonyltransferase activity PMID:25818647

6) Name: histone butyryltransferase activity Definition: Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone. child of Protein butyryltransferase activity PMID:27105113

pgaudet commented 7 years ago

Hello @sylvainpoux

I created the following terms: [Term] +id: GO:0140064 +name: peptide crotonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide." [PMID:25818647] +synonym: "protein crotonyltransferase activity" RELATED [] +is_a: GO:0008080 ! N-acetyltransferase activity +created_by: pg +creation_date: 2017-07-20T16:40:57Z + +[Term] +id: GO:0140065 +name: peptide butyryltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide." [PMID:27105113] +synonym: "protein butyryltransferase activity" RELATED [] +is_a: GO:0008080 ! N-acetyltransferase activity +created_by: pg +creation_date: 2017-07-20T16:46:49Z + +[Term] +id: GO:0140066 +name: peptidyl-lysine crotonylation +namespace: biological_process +def: "The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid." [PMID:25818647, Wikipedia:crotonyl] +is_a: GO:0043543 ! protein acylation +created_by: pg +creation_date: 2017-07-20T16:48:58Z + +[Term] +id: GO:0140067 +name: peptidyl-lysine butyrylation +namespace: biological_process +def: "The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid." [PMID:27105113, Wikipedia:butyryl] +is_a: GO:0043543 ! protein acylation +created_by: pg +creation_date: 2017-07-20T16:52:19Z + +[Term] +id: GO:0140068 +name: histone crotonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone." [PMID:25818647] +is_a: GO:0140064 ! peptide crotonyltransferase activity +created_by: pg +creation_date: 2017-07-20T16:55:16Z + +[Term] +id: GO:0140069 +name: histone butyryltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone." [PMID:27105113] +is_a: GO:0140065 ! peptide butyryltransferase activity +created_by: pg +creation_date: 2017-07-20T16:56:33Z +

A few comments:

  1. I modified the name of 'protein crotonyltransferase activity' and 'protein butyryltransferase activity' to peptide to match the neighboring terms. I added your term names as synonyms.

  2. Do you think we should create a general parent 'peptide N-acyltransferase activity' to group all these related modifications ?

Thanks, Pascale