currently
0005764 lysosome
0005771 multivesicular body
but from
http://www.biology.utah.edu/faculty2.php?inum=97
"the topological problem of
degrading plasma membrane proteins in the lumen of
the lysosome is solved in the formation of endosomal
structures called 'multivesicular bodies' (MVBs). MVBs
are part of the endosomal system of eukaryotic cells
and are formed by invagination and budding of vesicles
from the limiting membrane of endosomes into the lumen
of the compartment. During this process only endosomal
transmembrane proteins destined for degradation are
sorted into the forming vesicles and eventually
delivered to the lysosome"
and from
PMID: 11566881
Yeast endosomes, like those in animal cells, invaginate
their membranes to form internal vesicles. The
resulting multivesicular bodies fuse with the vacuole,
the lysosome equivalent, delivering the internal
vesicles for degradation.
so wouldn't 'late endosome' be a more appropriate
parent?
Add synonym MVB
currently 0005764 lysosome 0005771 multivesicular body
but from
http://www.biology.utah.edu/faculty2.php?inum=97 "the topological problem of degrading plasma membrane proteins in the lumen of the lysosome is solved in the formation of endosomal structures called 'multivesicular bodies' (MVBs). MVBs are part of the endosomal system of eukaryotic cells and are formed by invagination and budding of vesicles from the limiting membrane of endosomes into the lumen of the compartment. During this process only endosomal transmembrane proteins destined for degradation are sorted into the forming vesicles and eventually delivered to the lysosome"
and from PMID: 11566881 Yeast endosomes, like those in animal cells, invaginate their membranes to form internal vesicles. The resulting multivesicular bodies fuse with the vacuole, the lysosome equivalent, delivering the internal vesicles for degradation.
so wouldn't 'late endosome' be a more appropriate parent?
Reported by: ValWood
Original Ticket: "geneontology/ontology-requests/1535":https://sourceforge.net/p/geneontology/ontology-requests/1535