protein serine/threonine kinase activity definition

[gocentral]

Gillian, (a FB curator) pointed out that some of the protein kinase definitions need a little tweaking:

term: protein serine/threonine kinase activity goid: GO:0004674 definition: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. definition_reference: EC:2.7.1.37 > Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate.

[to be consistent with protein-tyrosine kinase activity ; GO:0004713]

term: protein serine/threonine phosphatase activity goid: GO:0004722 definition: Catalysis of the reaction: a phosphoprotein

• H2O = a protein + phosphate. definition_reference: EC:3.1.3.16 > Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate

[to be consistent with protein-tyrosine phosphatase activity ; GO:0004725]

term: protein serine/threonine phosphatase complex goid: GO:0008287 definition: An enzyme that catalyzes the removal of a phosphate group from a protein. definition_reference: EC:3.1.3.16 > A complex, often consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.

Becky

Reported by: beckyfoulger

Original Ticket: "geneontology/ontology-requests/1566":https://sourceforge.net/p/geneontology/ontology-requests/1566

[gocentral]

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my suggestion is for including the following statement depending on the term. Just giving the reaction may not serve the purpose of teaching the non-biochemist.

"phosphorylation" and/or "dephosphorylation" of the serine/threonine residue in a protein molecule

and may inlcude "this activity is shown by the proteins often carrying the LRR domians and those involved in defense/signal transduction pathways".

Original comment by: jaiswalp

[gocentral]

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Hi Pankaj, These defs sound a little process-like, but I'm happy to add sentences rather than a reaction. eg Catalysis of the removal/addition of a phosphate group from/to a serine or threonine residue in a protein molecule.

The definitions for the protein tyrosine kinase terms are currently reactions (from the EC site) and I think if we change the serine/threonine kinase defs to sentences, the same should be done for the tyrosine kinase defs.

Thanks, Becky

Original comment by: beckyfoulger

[gocentral]

• assigned_to: nobody --> beckyfoulger

Original comment by: beckyfoulger

[gocentral]

Logged In: YES user_id=482748

Fixed. Kept the definitions as reactions to be consistent with other function terms, particularly protein-tyrosine kinase activity ; GO:0004713 etc.

Therefore the new definitions are as follows: term: protein serine/threonine kinase activity goid: GO:0004674 Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. definition_reference: FB:bf # term: protein serine/threonine phosphatase activity goid: GO:0004722 Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. definition_reference: FB:bf # term: protein serine/threonine phosphatase complex goid: GO:0008287 A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. definition_reference: FB:bf

Original comment by: beckyfoulger

[gocentral]

• status: open --> open-fixed

Original comment by: beckyfoulger

[gocentral]

Logged In: YES user_id=482748

Fixed. Kept the definitions as reactions to be consistent with other function terms, particularly protein-tyrosine kinase activity ; GO:0004713 etc.

Therefore the new definitions are as follows: term: protein serine/threonine kinase activity goid: GO:0004674 Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. definition_reference: FB:bf # term: protein serine/threonine phosphatase activity goid: GO:0004722 Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. definition_reference: FB:bf # term: protein serine/threonine phosphatase complex goid: GO:0008287 A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. definition_reference: FB:bf

Original comment by: beckyfoulger

[gocentral]

• status: open-fixed --> closed-fixed

Original comment by: beckyfoulger