Add Wnt/B-catenin asymmetry pathway as new child of Wnt signaling pathway

[vanaukenk]

Propose to add a new term to annotate C. elegans genes to a more specific child of 'Wnt signaling pathway' (GO:0016055) for the cell fate specification pathway in the early embryo that combines elements of canonical and non-canonical Wnt signaling.

GO:new Wnt/B-catenin asymmetry pathway

Def.: The series of molecular signals initiated by the binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors that may include components of canonical Wnt signaling, such as beta-catenin, as well as MAPKKK and/or MAPK. The Wnt/B-catenin asymmetry pathway polarizes a mother cell leading to asymmetric inheritance of effectors and alternative daughter cell fates as a result of lineage-specific differences in TCF activity and transcriptional programs.

PMID:19619489 PMID:24058829 PMID:28409301

[vanaukenk]

@ukemi Here's a revised definition. I'm still not sure I'm completely happy with it, so if you have other suggestions for improvement and/or clarification, please let me know. Thx.

is_a GO:0016055 Wnt signaling pathway GO:new Wnt/Beta-catenin asymmetry pathway

The series of molecular signals initiated by the binding of a Wnt protein to a Frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors that include protein kinases, beta-catenins, and a TCF/LEF transcription factor. In C. elegans, the Wnt/Beta-catenin asymmetry pathway polarizes a mother cell, leading to reciprocal, asymmetric levels of effectors in the resulting daughter cells. Asymmetric distribution of effectors gives rise to lineage-specific differences in TCF/LEF transcriptional activity and thus, distinct daughter cell fates.

PMID:19619489, PMID:24058829, PMID:28409301