astrocytes are not immune cells

geneontology / go-ontology

Source ontology files for the Gene Ontology

http://geneontology.org/page/download-ontology

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astrocytes are not immune cells #1624

Closed gocentral closed 9 years ago

gocentral commented 20 years ago

GO:0045321 : immune cell activation (374) GO:0048143 : astrocyte activation (5)

Astrocytes are glial cells (only exist in the brain and support neurons; they are not found in the blood), so they are currently mis-classified as immune cells.

Reported by: *anonymous

Original Ticket: "geneontology/ontology-requests/1627":https://sourceforge.net/p/geneontology/ontology-requests/1627

gocentral commented 20 years ago

Logged In: YES user_id=436423

moved from DAG-Edit (i.e. software) bug tracker

Original comment by: mah11

gocentral commented 20 years ago

labels: --> Other term-related request

Original comment by: mah11

gocentral commented 20 years ago

Logged In: YES user_id=436423

The placement of astrocyte activation is probably OK: several papers, including those cited for the definition of GO:0048143, indicate that astrocytes contribute to the regulation of immune processes in the central nervous system. For example, they can secrete cytokines, express MHC Class II molecules, and may present antigens.

So although astrocytes do not circulate, they can be said to fit a broader concept of 'immune cell'.

Original comment by: mah11

gocentral commented 20 years ago

status: open --> closed-works-for-me

Original comment by: mah11