'translation factor activity, nucleic acid binding' versus 'translation repressor activity, non-nucleic acid binding'

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'translation factor activity, nucleic acid binding' versus 'translation repressor activity, non-nucleic acid binding' #16744

Open pgaudet opened 5 years ago

pgaudet commented 5 years ago

Hello,

I am not clear what 'translation factor activity, nucleic acid binding' versus 'translation repressor activity, non-nucleic acid binding' are supposed to represent.

GO:0045183 translation factor activity, non-nucleic acid binding: single annotation by MGI MGI:1334263 to a ubiquitin ligase activity. It seems that the process of 'repression of translation' was captured here, rather than a real function.
GO:0000901 translation repressor activity, non-nucleic acid binding : Since ISO by MGI - link doesn't work.

@hdrabkin would you be OK if I merged these terms into their respective parents ?

Thanks, Pascale

pgaudet commented 5 years ago

(Note to self: the next step would probably be to also merge the nucleic acid binding terms, since this is probably the mechanism by which these proteins mediate activation/repression of ~transcription~.) translation

ValWood commented 5 years ago

Hi @pgaudet are these about trancription or translation?

pgaudet commented 5 years ago

translation.

I'd like to finish MF refactoring

ValWood commented 5 years ago

OK edited above.I get it now but do there work on RNA not just "nucleic acid"

pgaudet commented 5 years ago

I dont understand your question.. Please rephrase

ValWood commented 5 years ago

I don't understand why the term is "nucleic acid binding". Shouldn't it be RNA binding (i.e are there translational repressors that bind to DNA?)

pgaudet commented 5 years ago

Oh! yes there are also children

'translation regulator activity'

'translation factor activity, non-nucleic acid binding' -- 'translation repressor activity, non-nucleic acid binding'

--'translation activator activity' (note that this one is a child of 'nucleic acid binding', but since this is not in the term name I dont think all proteins are nucleic acid binding

-'translation regulator activity, nucleic acid binding' --'translation repressor activity, mRNA regulatory element binding'

What I am proposing in short is this:

'translation regulator activity'

'translation activator activity'
'translation repressor activity'

Pascale