Closed pgaudet closed 5 years ago
Based on the definition "Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction."
it sounds as though this term was meant for the host genes involved in this pathway, but the term name sounds as though it applies to the pathogen.
There is also this term, describing the same process:
pattern recognition receptor signaling pathway Biological Process GO:0002221 Definition Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. PMID:15199967
and, I think I have seen others....
You said that. I agree that 'pattern recognition receptor signaling pathway'? is the correct branch to annotate the host genes to.
OK, so annotations should be moved. I'll open an annotation ticket.
pathogen-associated molecular patterns (or PAMPs) occur in microbes that I think would only be the symbionts and this would not occur in the hosts. So the proposed merge would likely be ok in this case - although I'm hesitant about making these merges since I'm not an expert on the biology in this area. I'll see if I can track down any PAMGO people who have this expertise.
One thing we might want to consider is either changing this to microbe-associated molecular pattern (MAMP), or making a new MAMP term, that would be able to be used with non-pathogens who can also elicit the same response.
Hello,
Concerning your first point Pascale, the term GO:0002752 cell surface pattern recognition receptor signaling pathway", is too restrictive since there are plenty of PAMP receptors that are cytoplasmic such as RIG-I or MDA-5, even if they are termed receptors, they are never found on the cell surface...So, as Val said the term GO:0002221 "pattern recognition receptor signaling pathway" is better for host proteins involved in the pathway. Concerning the pathogens, we have two different parts: 1- Do we want to capture the PAMP themselves (can be dsDNA ssRNA or bacterial proteins for example): 2- Do we want to capture the proteins from the pathogens that actually modulate the PAMP receptor pathway (mostly inhibition). For example we have several terms for viruses such as: GO:0039722: suppression by virus of host toll-like receptor signaling pathway GO:0039538 : suppression by virus of host RIG-I signaling pathway which are PAMPs. In that case we should have more general terms such as "modulation by pathogens of host pattern recognition receptor signaling pathway" The two GO terms Pascale mentioned are quite misleading GO:0052308 and GO:0052169, I don't see what they want to capture. Patrick.
Hi Patrick,
1- Do we want to capture the PAMP themselves (can be dsDNA ssRNA or bacterial proteins for example):
Here my immediate thought was no, because this isn't the 'purpose' of the PAMP from the pathogen perspective? (although you might want to capture the type of PAMP in an extension (i.e chitin fragment for a yeast, or RNA, protein etc, also presumably it isn't the entire molecule).
2- Do we want to capture the proteins from the pathogens that actually modulate the PAMP receptor pathway (mostly inhibition). For example we have several terms for viruses such as: GO:0039722: suppression by virus of host toll-like receptor signaling pathway GO:0039538 : suppression by virus of host RIG-I signaling pathway which are PAMPs. In that case we should have more general terms such as "modulation by pathogens of host pattern recognition receptor signaling pathway"
Here I think yes because this is an "evolved" function. But because it gets so complicated I wondered here https://github.com/geneontology/go-ontology/issues/16909 If it is better to keep the concepts like pathogenicity/mutualism/symbiosis out of GO. It might even be better to keep virus,fungi,oomycete out too (maybe even an extension could capture the species). This would prevent the explosion of terms and make it much easier to find things.
Yes sure, We could have just "modulation of pattern recognition receptor signaling pathway" and mention somewhere else if it's viral or bacterial or else. We had this discussion for GO-CAM for models with different species. Instead of using terms such as "inhibition by virus" we would just put a molecular function for the viral protein and put somewhere the context ( Ex Model in the context of a viral infected cell for example) and we could get rid of these terms . Jim Hu suggested this kind of approach.
I really, really like that plan. I'm lost in these terms!
I like @pmasson55 's suggestion as well - and it's consistent with the other terms you mention. Right now we have two parallel ways of describing how the symbiont affects the host.
So, it seems like all 4 terms should be obsoleted, since they have been misused, and new terms created when we have proteins to annotate ?
(The 4 terms being: 'pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction'
'pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction'
'pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response' 'pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response' )
Thanks, Pascale
Obsoletion of GO:0052308 pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction and children
Dear all,
The proposal has been made to obsolete:
'GO:0052308 pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction’ 0 annotations
'GO:0052257 pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction’ 0 annotations
'GO:0052033 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response’ 13 annotations
'GO:0052169 pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response’ 2 annotations
The reason for obsoletion is that the terms have been misused (and are being fixed, see https://github.com/geneontology/go-annotation/issues/2296) The terms 'GO:0002221 pattern recognition receptor signaling pathway' or 'GO:0002752 cell surface pattern recognition receptor signaling pathway’ are more appropriate for annotation of host proteins.
Symbiont protein can be potentially be annotated to 'GO:0052034 negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immune response’
These terms are not part of any slims (subsets). There are no mappings to these terms.
Any comments can be added to the issue: #17040
We are opening a comment period for this proposed obsoletion. We’d like to proceed and obsolete this term on March 25th, 2019. Unless objections are received by March 25th, 2019. we will assume that you agree to this change.
Thanks, Pascale
Hi, Couple questions -
Is there a plan to make the term Patrick suggested - 'modulation of pattern recognition receptor signaling pathway'? Or rather stick with the existing term 'modulation by symbiont of microbe-associated molecular pattern-induced host innate immune response'?
I'd like to create the term, however I'd like an example (ie, a paper to cite in the new term). Right now we only have host proteins annotated.
For the microbe proteins that are the actual PAMPs, is the thought to annotate to 'pattern recognition receptor signaling pathway' in a GO-CAM and somehow indicate this is in the host? Or would that information not be captured?
We could annotate to 'modulation of host pattern recognition receptor signaling pathway'; would that work ? I would like to ask though - what are we really trying to capture ? As far as I understand the PAMPs are a protein family that are recognized by the host, which triggers a defense response. Certainly the microbe is NOT trying to alert the host to its presence, so in that sense this is quite similar to a 'hijacked' function of the symbiont protein by the host.
But I suppose that the use case here is to find all pathogen proteins that can elicit an immune response, is this correct ? Can we think of a more direct way to express that ? Thinking out loud: how about 'induction by symbiont of host pattern recognition receptor signaling pathway' ?
And then proteins could also be annotated to the MF 'signaling receptor binding'.
What do you think ?
Pascale
Certainly the microbe is NOT trying to alert the host to its presence, so in that sense this is quite similar to a 'hijacked' function of the symbiont protein by the host.
I thought the same See Kim Hammond-Kosacks comment in another ticket. (https://github.com/geneontology/go-ontology/issues/17014#issuecomment-473312413)
Sometimes the pathogen intentionally activates this pathway to kill host tissue if it has a necrotic lifestyle.
Oh sorry, getting confused. That is in the hypersensitive cell death pathway (2nd response). It might not apply to PRR signalling. I don't know. Anyone?
This is where I need someone with more knowledge of these processes. I've contacted Alan and Candace Collmer - two PAMGO people - I'm hoping they will be able to help out with some of these questions.
@mgiglio99 Any news ?
Re> For the microbe proteins that are the actual PAMPs, is the thought to annotate to 'pattern recognition receptor signaling pathway' in a GO-CAM and somehow indicate this is in the host? Or would that information not be captured?
we have annotated there to terms like GO:0052552 modulation by organism of immune response of other organism involved in symbiotic interaction for effectors,
I don't think the viral terms should be annotated directly to the host pathways. Or at least right now we should clean up the existing first so we make sure we aren't duplicating.
Can we go ahead with the main part of this one and put any outstanding in new tickets? Action seems to be clear?
It seems that when the pathogen proteins have been annotated they all follow the pattern
"modulation by symbiont of host blah" for example modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
I don't know if this is the most efficient way to do this. We might consider using extensions for this? but it shouldn't impact the changes in this ticket.
Obsoletions: 'GO:0052308 pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction’ 0 annotations
This term was obsoleted because it has been misused.
Consider: GO:0002221 GO:0002752 GO:0052034
I am obsoleting the 4 terms. @mgiglio99 @ValWood Can you open new tickets for whatever other tasks need to be done ?
WRT to the proposed new term 'modulation of pattern recognition receptor signaling pathway' - right now we have in the ontology
Do we need other terms ? Please open a new ticket if we do
Thanks, Pascale
I don't think we need to add new terms right now -there are still too many terms;).
I'm pretty sure that this branch is covered in other tickets and will be adressed in due course. Val
Hello,
'GO:0052308 pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction' is defined as "Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction."
I take it to mean that symbiont gene products should be annotated, but all annotations are to host gene products: https://docs.google.com/spreadsheets/d/1EwF_QPEXzfMxkxUuRCipwzmpaGeTb2VfcDacoKkOPGA/edit#gid=0
I think annotations should be moved to GO:0002752 @tberardini @sabrinatoro @milarolo
What do you recommend @jimhu-tamu @mgiglio99 @cmungall @pmasson55 @nsuvarnaiari @jrr-cpt?
Thanks, Pascale