Closed gocentral closed 9 years ago
gocentral
commented
20 years ago Logged In: YES user_id=463625
Hi Alex
I'm not sure of the 'directed killing' part of your definition...do you think your defs work well for toxins.. Not sure of cytotoxicity being = to cytolysis either.. I think cytotoxicity can occur without eventually causing cytolysis...what do you think?
perhaps we can discuss these more at the annotation camp.. cheers Evelyn
Original comment by: ecamon
gocentral
commented
20 years ago Logged In: YES user_id=482944
Hello, I have to agree with Evelyn that I don't think "cytolysis" = "cytotoxicity". Also, it seems that the spur to changing the definition of this term in GO is because people in the T-cell, NK cell, and ADCC communities are inappropriately calling their process "cytolysis". In my experience "cytolysis" always refers to a rupture of membranes. I agree that GO needs a "cell killing" term of which "cytolysis" should be a child. I suggested one back in the winter - that whole thread has been put on hold until the next content meeting in August since there seemed to be difficulty in reaching consensus (over the pathogenesis issue). In addition, there is an effort underway by a group called PAMGO that will be suggesting some new "cell killing" terms to the GO in the very near future. Perhaps a generic "cell killing" term is the better way to go rather than redefining something which, I think, has a pretty clear biological meaning. Just my two cents... Michelle
Original comment by: mlgwinn
gocentral
commented
20 years ago Logged In: YES user_id=865072
Evelyn and Michelle,
I'm quite happy to shift the cytotoxicity terms to be children of a new immune cell mediated cytotoxicity term, rather than to be children of cytolysis. In fact that's how I originally wrote up the entry. I switched to having these terms under cytolysis because somebody earlier had placed natural killer mediated cytolysis under cytolysis. This was not a surprise to me, because immunologists had long used the term cytolysis as a synonym for NK and T cell killing of target cells, due to an earlier misunderstanding of the mechanisms involved. When I started in immunology, it was thought that perforin release from these cell types literally lysed the target cells, although now it is known that perforin acts in physiological settings only to facilitate the entrance of granzymes into the target cells. I assumed therefore that cytolysis was being used in the GO with a broader meaning, and thought I should bring the definition in line with that.
Anyway, it makes sense to separate T-cell mediated cytotoxicity, NK cell mediated cytotoxicity, and ADCC, all of which share common elements, away from cytolysis, which then can be reserved for nasty microbial gene products and perhaps C9 and other members of the complement cascade.
Regarding the "directed killing" part of my definitions, my intention is for these terms to be used to describe contact- dependent killing of target cells by immune system cells (in many or most situations following the formation of an immunological synapse), not for the random killing of susceptible cells following the release of cytokines in the broader environment.
Since I do not then wish to change the GO definition of cytolysis, and want remove the immune system-related terms from being its children, I do not believe that this entry then bears on the issue of pathogenesis or toxins and therefore the terms can be entered in the near term. We really need a "T-cell mediated cytotoxicity" term in the GO, as this phenomenon is central to immune responses to virally and bacterially infected cells. Also, at the moment I do not think an additional "cell killing" term is needed in the GO, since GO:0008219 cell death already exists as grouping term.
Thus, I have made appropriate changes below.
-- Alex
The new DAG
GO:0008219 ; cell death --% GO:0019835 ; cytolysis ----% GO:0019836 ; hemolysis ----< GO:0042268 ; regulation of cytolysis ------% GO:0045918 ; negative regulation of cytolysis ------% GO:0045919 ; positive regulation of cytolysis --% GO:NewTerm ; immune cell mediated cytotoxicity ----% GO:NewTerm ; T-cell mediated cytotoxicity ------< GO:NewTerm ; regulation of T-cell mediated cytotoxicity --------% GO:NewTerm ; negative regulation of T-cell mediated cytotoxicity --------% GO:NewTerm ; positive regulation of T-cell mediated cytotoxicity ----% GO:0042267 ; natural killer cell mediated cytotoxicity [as renamed] ------< GO:0042269 ; regulation of natural killer cell mediated cytotoxicity [as renamed] --------% GO:0045953 ; negative regulation of natural killer cell mediated cytotoxicity [as renamed] ----------% GO:0042270 ; protection from natural killer cell mediated cytotoxicity [as renamed] --------% GO:0045954 ; positive regulation of natural killer cell mediated cytotoxicity [as renamed] ----------% GO:0042271 ; susceptibility to natural killer cell mediated cytotoxicity [as renamed] ----% GO:0001788 ; antibody-dependent cellular cytotoxicity ------< GO:0001813 ; regulation of antibody-dependent cellular cytotoxicity --------% GO:0001814 ; negative regulation of antibody-dependent cellular cytotoxicity --------% GO:0001815 ; positive regulation of antibody-dependent cellular cytotoxicity ----< GO:NewTerm ; regulation of immune cell mediated cytotoxicity ------% GO:NewTerm ; negative regulation of immune cell mediated cytotoxicity --------% GO:NewTerm ; negative regulation of T-cell mediated cytotoxicity --------% GO:0045953 ; negative regulation of natural killer cell mediated cytotoxicity [as renamed] ----------% GO:0042270 ; protection from natural killer cell mediated cytotoxicity [as renamed] --------% GO:0001814 ; negative regulation of antibody-dependent cellular cytotoxicity ------% GO:NewTerm ; positive regulation of immune cell mediated cytotoxicity --------% GO:NewTerm ; positive regulation of T-cell mediated cytotoxicity --------% GO:0045954 ; positive regulation of natural killer cell mediated cytotoxicity [as renamed] ----------% GO:0042271 ; susceptibility to natural killer cell mediated cytotoxicity [as renamed] --------% GO:0001815 ; positive regulation of antibody-dependent cellular cytotoxicity ------% GO:NewTerm ; regulation of T-cell mediated cytotoxicity --------% GO:NewTerm ; negative regulation of T-cell mediated cytotoxicity --------% GO:NewTerm ; positive regulation of T-cell mediated cytotoxicity ------% GO:0042269 ; regulation of natural killer cell mediated cytotoxicity [as renamed] --------% GO:0045953 ; negative regulation of natural killer cell mediated cytotoxicity [as renamed] ----------% GO:0042270 ; protection from natural killer cell mediated cytotoxicity [as renamed] --------% GO:0045954 ; positive regulation of natural killer cell mediated cytotoxicity [as renamed] ----------% GO:0042271 ; susceptibility to natural killer cell mediated cytotoxicity [as renamed] ------% GO:0001813 ; regulation of antibody-dependent cellular cytotoxicity --------% GO:0001814 ; negative regulation of antibody-dependent cellular cytotoxicity --------% GO:0001815 ; positive regulation of antibody-dependent cellular cytotoxicity
1) New Term: immune cell mediated cytotoxicity
Synonym: immune cell mediated cell killing [=]
Synonym: immune cell mediated cell death [=]
Definition: The directed killing of a target cell by a by an immune cell.
Parentage: is-a to GO:0008219 cell death and is-a to GO:0042087 cell-mediated immune response.
Comment: This term and its children are meant to describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system.
Reference: ISBN:0781735149, PMID:11911826
2) New term: regulation of immune cell mediated cytotoxicity
Synonym: regulation of immune cell mediated cell killing [=]
Synonym: regulation of immune cell mediated cell death [=]
Definition: Any process that modulates the frequency, rate, or extent of immune cell mediated cytotoxicity.
Parentage: part-of to "immune cell mediated cytotoxicity," above
Reference: ISBN:0781735149, PMID:11911826
3) New term: negative regulation of immune cell mediated cytotoxicity
Synonym: negative regulation of immune cell mediated cell killing [=]
Synonym: negative regulation of immune cell mediated cell death [=]
Definition: Any process that stops, prevents, or reduces the rate of immune cell mediated cytotoxicity.
Parentage: is-a to "regulation of immune cell mediated cytotoxicity," above
Reference: ISBN:0781735149, PMID:11911826
4) New term: positive regulation of immune cell mediated cytotoxicity
Synonym: positive regulation of immune cell mediated cell killing [=]
Synonym: positive regulation of immune cell mediated cell death [=]
Definition: Any process that activates or increases the rate of immune cell mediated cytotoxicity.
Parentage: is-a to "regulation of immune cell mediated cytotoxicity," above
Reference: ISBN:0781735149, PMID:11911826
5) New Term: T-cell mediated cytotoxicity
Synonym: T cell mediated cytotoxicity [=]
Synonym: T-cell mediated apoptosis [=]
Synonym: T cell mediated apoptosis [=]
Synonym: T-cell mediated cell killing [=]
Synonym: T cell mediated cell killing [=]
Synonym: T-cell mediated cell death [=]
Synonym: T cell mediated cell death [=]
Synonym: T-cell mediated cytolysis [~]
Synonym: T cell mediated cytolysis [~]
Definition: The directed killing of a target cell by a T-cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Parentage: is-a to immune cell mediated cytotoxicity and is-a to GO:00069174 induction of apoptosis.
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process.
Comment: Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell.
Comment: Note that both CD4 and CD8 positive T-cells can mediate apoptosis of target cells, independently of their definition as "helper" T-cells or not.
Reference: ISBN:0781735149, PMID:11911826
[Editorial note: although isolated perforin has been shown to induce cytolysis directly when applied to target cells at high concentrations, experimental evidence shows that the function of perforin is to allow access of granzymes into the cytoplasm of the target cell, followed by the granzyme mediated cleavage of caspase and non-caspase components of the apoptotic pathway leading to the induction of apoptosis.]
6) New Term: regulation of T-cell mediated cytotoxicity
Synonym: regulation of T cell mediated cytotoxicity [=]
Synonym: regulation of T-cell mediated apoptosis [=]
Synonym: regulation of T cell mediated apoptosis [=]
Synonym: regulation of T cell mediated cell killing [=]
Synonym: regulation of T-cell mediated cell killing [=]
Synonym: regulation of T-cell mediated cell death [=]
Synonym: regulation of T cell mediated cell death [=]
Synonym: regulation of T-cell mediated cytolysis [~]
Synonym: regulation of T cell mediated cytolysis [~]
Definition: Any process that modulates the frequency, rate, or extent of T-cell mediated cytotoxicity.
Parentage: part-of to "T-cell mediated cytotoxicity" and is-a to "regulation of immune cell mediated cytotoxicity," above.
Reference: ISBN:0781735149
7) New Term: negative regulation of T-cell mediated cytotoxicity
Synonym: negative regulation of T cell mediated cytotoxicity [=]
Synonym: negative regulation of T-cell mediated apoptosis [=]
Synonym: negative regulation of T cell mediated apoptosis [=]
Synonym: negative regulation of T cell mediated cell killing [=]
Synonym: negative regulation of T-cell mediated cell killing [=]
Synonym: negative regulation of T-cell mediated cell death [=]
Synonym: negative regulation of T cell mediated cell death [=]
Synonym: negative regulation of T-cell mediated cytolysis [~]
Synonym: negative regulation of T cell mediated cytolysis [~]
Definition: Any process that stops, prevents, or reduces the rate of T-cell mediated cytotoxicity.
Parentage: is-a to "regulation of T-cell mediated cytotoxicity" and is-a to "negative regulation of immune cell mediated cytotoxicity," above.
Reference: ISBN:0781735149
8) New Term: positive regulation of T-cell mediated cytotoxicity
Synonym: positive regulation of T cell mediated cytotoxicity [=]
Synonym: positive regulation of T-cell mediated apoptosis [=]
Synonym: positive regulation of T cell mediated apoptosis [=]
Synonym: positive regulation of T cell mediated cell killing [=]
Synonym: positive regulation of T-cell mediated cell killing [=]
Synonym: positive regulation of T-cell mediated cell death [=]
Synonym: positive regulation of T cell mediated cell death [=]
Synonym: positive regulation of T-cell mediated cytolysis [~]
Synonym: positive regulation of T cell mediated cytolysis [~]
Definition: Any process that activates or increases the rate of T- cell mediated cytotoxicity.
Parentage: is-a to "regulation of T-cell mediated cytotoxicity" and is-a to "positive regulation of immune cell mediated cytotoxicity," above.
Reference: ISBN:0781735149
9) GO:0042267 natural killer cell mediated cytolysis
This term needs to be renamed and redefined to parallel the T-cell mediated cytotoxicity term, because the mechanisms of cell killing used by NK cells are nearly identical to those of T cells, and involve the induction of apoptosis in the target cells.
Proposed new name: natural killer cell mediated cytotoxicity
Synonym (new): NK cell mediated cytotoxicity [=]
Synonym (new): natural killer cell mediated cytolysis [~]
Synonym (old): NK cell mediated cytolysis [~]
Synonym (old): natural killer-cell mediated cytolysis [~]
Proposed new definition: The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Revised parentage: is-a to "immune cell mediated cytotoxicity," above, and is-a to GO:00069174 induction of apoptosis
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process.
Comment: Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
10) GO:0042269 regulation of natural killer cell mediated cytolysis
Proposed new name: regulation of natural killer cell mediated cytotoxicity
Synonym (new): regulation of NK cell mediated cytotoxicity [=]
Synonym (new): regulation of natural killer cell mediated cytolysis [~]
Synonym (old): regulation of NK cell mediated cytolysis [~]
Synonym (old): regulation of natural killer-cell mediated cytolysis [~]
Proposed new definition: Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.
Revised parentage: part-of to GO:0042267 natural killer cell mediated cytotoxicity [as renamed] and to "regulation of immune cell mediated cytotoxicity," above.
Reference: ISBN:0781735149
11) GO:0045953 negative regulation of natural killer cell mediated cytolysis
Proposed new name: negative regulation of natural killer cell mediated cytotoxicity
Synonym (new): negative regulation of NK cell mediated cytotoxicity [=]
Synonym (new): negative regulation of natural killer cell mediated cytolysis [~]
Synonym (old): negative regulation of NK cell mediated cytolysis [~]
Proposed new definition: Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.
Revised parentage: is-a to GO:0042269 regulation of natural killer cell mediated cytotoxicity [as renamed] and to "negative regulation of immune cell mediated cytotoxicity," above.
Reference: ISBN:0781735149
12) GO:0045954 positive regulation of natural killer cell mediated cytolysis
Proposed new name: positive regulation of natural killer cell mediated cytotoxicity
Synonym (new): positive regulation of NK cell mediated cytotoxicity [=]
Synonym (new): positive regulation of natural killer cell mediated cytolysis [~]
Synonym (old): positive regulation of NK cell mediated cytolysis [~]
Proposed new definition: Any process that activates or increases the rate of natural killer cell mediated cytotoxicity.
Revised parentage: is-a to GO:0042269 regulation of natural killer cell mediated cytotoxicity [as renamed] and to "positive regulation of immune cell mediated cytotoxicity," above.
Reference: ISBN:0781735149
13) GO:0042270 protection from natural killer cell mediated cytolysis
Proposed new name: protection from natural killer cell mediated cytotoxicity
Synonym (new): protection from NK cell mediated cytotoxicity [=]
Synonym (new): protection from natural killer cell mediated cytolysis [~]
Synonym (old): protection from NK cell mediated cytolysis [~]
Proposed new definition: The process of protecting a cell from natural killer cell mediated cytotoxicity.
Revised parentage: is-a to GO:0045953 negative regulation of natural killer cell mediated cytotoxicity [as renamed above].
Comment: Note that this term is intended for cell-surface molecules on a target cell which interact with inhibitory receptors on a natural killer cell to prevent natural killer cell mediated cytotoxicity.
[Editorial note: This is clearly a type of negative regulation of NK cell cytotoxicity and its position in the DAG should reflect that.]
14) GO:0042271 susceptibility to natural killer cell mediated cytolysis
Proposed new name: susceptibility to natural killer cell mediated cytotoxicity
Synonym (new): susceptibility to NK cell mediated cytotoxicity [=]
Synonym (new): susceptibility to natural killer cell mediated cytolysis [~]
Synonym (old): susceptibility to NK cell mediated cytolysis [~]
Proposed new definition: The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.
Revised parentage: is-a to GO:0045954 positive regulation of natural killer cell mediated cytotoxicity [as renamed above].
Comment: Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity.
[Editorial note: This is clearly a type of positive regulation of NK cell cytotoxicity and its position in the DAG should reflect that.]
15) GO:0001788 antibody-dependent cellular cytotoxicity
Proposed new definition: Killing of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
Revised parentage: is-a to "immune cell mediated cytotoxicity," above, and is-a to GO:00069174 induction of apoptosis
16) GO:0001813 regulation of antibody-dependent cellular cytotoxicity
Revised parentage: part-of to GO:0001788 antibody-dependent cellular cytotoxicity and is-a to "regulation of immune cell mediated cytotoxicity," above.
17) GO:0001814 negative regulation of antibody-dependent cellular cytotoxicity
Revised parentage: is-a to GO:0001813 regulation of antibody- dependent cellular cytotoxicity and is-a to "negative regulation of immune cell mediated cytotoxicity," above.
18) GO:0001815 positive regulation of antibody-dependent cellular cytotoxicity
Revised parentage: is-a to GO:0001813 regulation of antibody- dependent cellular cytotoxicity and is-a to "positive regulation of immune cell mediated cytotoxicity," above.
Original comment by: addiehl
gocentral
commented
20 years ago Logged In: YES user_id=865072
I have closed this item and incorporated the terms into a new sourceforge entry 1012931 discussing cell killing.
See you there and at Stanford,
Alex
Original comment by: addiehl
gocentral
commented
20 years ago Original comment by: addiehl
Cytolysis terms
The following terms need to be added to or changed in the GO. I apologize for the proliferation of synonyms.
Thanks,
Alex
1) GO:0019835 cytolysis
Synonym: lysis [<]
Proposed additional synonym: cytotoxicity [=]
Current definition: The rupture of cell membranes and the loss of cytoplasm.
Proposed new definition: The directed killing of target cells through apoptotic or non-apoptotic mechanisms.
The problem with the original definition is that, despite its etymological formation, the word cytolysis has been widely used to describe any type of killing of target cells, whether through apoptotic or non-apoptotic mechanisms. Indeed, it is now clear that T-cell killing of target cells through perforin dependent mechanisms, NK cell killing, and ADCC are all apoptotic mechanisms in physiological circumstances, yet these are still termed cytolysis, even though it is clear that large scale membrane rupture is not part of the process, and the loss of cytoplasm is through cellular blebbing.
Hemolysis is non-apoptotic and as defined in the GO, a lytic destruction of another organism's erythrocytes.
Thus, I believe the best way to capture the de facto meaning of cytolysis is to define it as essentially any means of killing target cells (whether self or non-self), and use other process and function terms to point to mechanistic features of particular processes.
Reference: ISBN:0781735149, PMID:11911826, PMID:14512315
2) GO:0042268 regulation of cytolysis
Current definition: Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm.
Proposed new definition: Any process that modulates the frequency, rate, or extent of cytolysis.
Reference: ISBN:0781735149, PMID:11911826, PMID:14512315
3) New Term: T-cell mediated cytotoxicity
Synonym: T cell mediated cytotoxicity [=]
Synonym: T-cell mediated apoptosis [=]
Synonym: T cell mediated apoptosis [=]
Synonym: T-cell mediated cell killing [=]
Synonym: T cell mediated cell killing [=]
Synonym: T-cell mediated cell death [=]
Synonym: T cell mediated cell death [=]
Synonym: T-cell mediated cytolysis [=]
Synonym: T cell mediated cytolysis [=]
Definition: The directed killing of a target cell by a T-cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Parentage: is-a to GO:0019835 cytolysis and is-a to GO:00069174 induction of apoptosis
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process.
Comment: Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell.
Comment: Note that both CD4 and CD8 positive T-cells can mediate apoptosis of target cells, independently of their definition as "helper" T-cells or not.
Reference: ISBN:0781735149, PMID:11911826
[Editorial note: although isolated perforin has been shown to induce cytolysis directly when applied to target cells at high concentrations, experimental evidence shows that the function of perforin is to allow access of granzymes into the cytoplasm of the target cell, followed by the granzyme mediated cleavage of caspase and non-caspase components of the apoptotic pathway leading to the induction of apoptosis.]
3) New Term: regulation of T-cell mediated cytotoxicity
Synonym: regulation of T cell mediated cytotoxicity [=]
Synonym: regulation of T-cell mediated apoptosis [=]
Synonym: regulation of T cell mediated apoptosis [=]
Synonym: regulation of T cell mediated cell killing [=]
Synonym: regulation of T-cell mediated cell killing [=]
Synonym: regulation of T-cell mediated cell death [=]
Synonym: regulation of T cell mediated cell death [=]
Synonym: regulation of T-cell mediated cytolysis [=]
Synonym: regulation of T cell mediated cytolysis [=]
Definition: Any process that modulates the frequency, rate, or extent of T-cell mediated cytotoxicity.
Parentage: part-of to "T-cell mediated cytotoxicity," above, and is-a to GO:0042268 regulation of cytolysis.
Reference: ISBN:0781735149
3) New Term: negative regulation of T-cell mediated cytotoxicity
Synonym: negative regulation of T cell mediated cytotoxicity [=]
Synonym: negative regulation of T-cell mediated apoptosis [=]
Synonym: negative regulation of T cell mediated apoptosis [=]
Synonym: negative regulation of T cell mediated cell killing [=]
Synonym: negative regulation of T-cell mediated cell killing [=]
Synonym: negative regulation of T-cell mediated cell death [=]
Synonym: negative regulation of T cell mediated cell death [=]
Synonym: negative regulation of T-cell mediated cytolysis [=]
Synonym: negative regulation of T cell mediated cytolysis [=]
Definition: Any process that stops, prevents, or reduces the rate of T-cell mediated cytotoxicity.
Parentage: is-a to "regulation of T-cell mediated cytotoxicity," above, and is-a to GO:0045918 negative regulation of cytolysis.
Reference: ISBN:0781735149
4) New Term: positive regulation of T-cell mediated cytotoxicity
Synonym: positive regulation of T cell mediated cytotoxicity [=]
Synonym: positive regulation of T-cell mediated apoptosis [=]
Synonym: positive regulation of T cell mediated apoptosis [=]
Synonym: positive regulation of T cell mediated cell killing [=]
Synonym: positive regulation of T-cell mediated cell killing [=]
Synonym: positive regulation of T-cell mediated cell death [=]
Synonym: positive regulation of T cell mediated cell death [=]
Synonym: positive regulation of T-cell mediated cytolysis [=]
Synonym: positive regulation of T cell mediated cytolysis [=]
Definition: Any process that activates or increases the rate of T-cell mediated cytotoxicity.
Parentage: is-a to "regulation of T-cell mediated cytotoxicity," above, and is-a to GO:0045919 positive regulation of cytolysis.
Reference: ISBN:0781735149
5) GO:0042267 natural killer cell mediated cytolysis
This term needs to be renamed and redefined to parallel the T-cell mediated cytotoxicity term, because the mechanisms of cell killing used by NK cells are nearly identical to those of T cells, and involve the induction of apoptosis in the target cells.
Proposed new name: natural killer cell mediated cytotoxicity
Synonym (new): NK cell mediated cytotoxicity
Synonym (new): natural killer cell mediated cytolysis
Synonym (old): NK cell mediated cytolysis
Synonym (old): natural killer-cell mediated cytolysis
Proposed new definition: The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Revised parentage: is-a to GO:0019835 cytolysis and is-a to GO:00069174 induction of apoptosis
Comment: Note that either or both mechanisms mentioned in the definition may be used in this process.
Comment: Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
6) GO:0042269 regulation of natural killer cell mediated cytolysis
Proposed new name: regulation of natural killer cell mediated cytotoxicity
Synonym (new): regulation of NK cell mediated cytotoxicity
Synonym (new): regulation of natural killer cell mediated cytolysis
Synonym (old): regulation of NK cell mediated cytolysis
Synonym (old): regulation of natural killer-cell mediated cytolysis
Proposed new definition: Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.
Reference: ISBN:0781735149
7) GO:0045953 negative regulation of natural killer cell mediated cytolysis
Proposed new name: negative regulation of natural killer cell mediated cytotoxicity
Synonym (new): negative regulation of NK cell mediated cytotoxicity
Synonym (new): negative regulation of natural killer cell mediated cytolysis
Synonym (old): negative regulation of NK cell mediated cytolysis
Proposed new definition: Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.
Reference: ISBN:0781735149
8) GO:0045954 positive regulation of natural killer cell mediated cytolysis
Proposed new name: positive regulation of natural killer cell mediated cytotoxicity
Synonym (new): positive regulation of NK cell mediated cytotoxicity
Synonym (new): positive regulation of natural killer cell mediated cytolysis
Synonym (old): positive regulation of NK cell mediated cytolysis
Proposed new definition: Any process that activates or increases the rate of natural killer cell mediated cytotoxicity.
Reference: ISBN:0781735149
9) GO:0042270 protection from natural killer cell mediated cytolysis
Proposed new name: protection from natural killer cell mediated cytotoxicity
Synonym (new): protection from NK cell mediated cytotoxicity
Synonym (new): protection from natural killer cell mediated cytolysis
Synonym (old): protection from NK cell mediated cytolysis
Proposed new definition: The process of protecting a cell from natural killer cell mediated cytolysis.
Proposed new parentage: is-a to GO:0045953 negative regulation of natural killer cell mediated cytotoxicity [as renamed above]; no other parents.
Comment: Note that this term is intended for cell-surface molecules on a target cell which interact with inhibitory receptors on a natural killer cell to prevent natural killer cell mediated cytotoxicity.
[Editorial note: This is clearly a type of negative regulation of NK cell cytotoxicity and its position in the DAG should reflect that.]
10) GO:0042271 susceptibility to natural killer cell mediated cytolysis
Proposed new name: susceptibility to natural killer cell mediated cytotoxicity
Synonym (new): susceptibility to NK cell mediated cytotoxicity
Synonym (new): susceptibility to natural killer cell mediated cytolysis
Synonym (old): susceptibility to NK cell mediated cytolysis
Proposed new definition: The process of causing a cell to become susceptible to natural killer cell mediated cytolysis.
Proposed new parentage: is-a to GO:0045954 positive regulation of natural killer cell mediated cytotoxicity [as renamed above]; no other parents.
Comment: Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity.
[Editorial note: This is clearly a type of positive regulation of NK cell cytotoxicity and its position in the DAG should reflect that.]
11) GO:0001788 antibody-dependent cellular cytotoxicity
Revised parentage: is-a to GO:0019835 cytolysis and is-a to GO:00069174 induction of apoptosis
12) GO:0001813 regulation of antibody-dependent cellular cytotoxicity
Revised parentage: part-of to GO:0001788 antibody- dependent cellular cytotoxicity and is-a to GO:0042268 regulation of cytolysis.
13) GO:0001814 negative regulation of antibody-dependent cellular cytotoxicity
Revised parentage: is-a to GO:0001813 regulation of antibody-dependent cellular cytotoxicity and is-a to GO:0045918 negative regulation of cytolysis.
14) GO:0001815 positive regulation of antibody-dependent cellular cytotoxicity
Revised parentage: is-a to GO:0001813 regulation of antibody-dependent cellular cytotoxicity and is-a to GO:0045919 positive regulation of cytolysis.
Reported by: addiehl
Original Ticket: "geneontology/ontology-requests/1760":https://sourceforge.net/p/geneontology/ontology-requests/1760