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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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new term request:long noncoding RNA binding #17769

Closed Argoudpuy closed 5 years ago

Argoudpuy commented 5 years ago

Hi, could you please create a new term Go corresponding to long noncoding RNA binding as a child of RNA binding. In fact in PMID:25578728, RBM7 binds many sort of RNA namely long non coding RNA see fig1 B. many thanks. Guilaine

hdrabkin commented 5 years ago

will also make lncRNA binding exact synonym.

A side note about these 'noncoding RNAs' I have come across miRNAs that in addition to having the traditional regulatory effects on translation, some have been shown to also be translated to yield short peptides with their onw function. (see PMID:25807486

We (MGI) also note that we see UniProtKB entries with proper methionine starts mapping to lncRNA genes; looking at the genomic we even see a polyA tail, so that they look like processed pseudogenes. If we see data that the protein really exists we may think about chaning the biotype from lncRNA to a protein-coding gene. See also PMID:27713758 My point is that if you annotated RBM7 to lncRNA binding; what if the RNA in question does in fact code for something.

hdrabkin commented 5 years ago

[Term] +id: GO:0106222 +name: long noncoding RNA binding