R-loop disassembly

[sylvainpoux]

Hi GO, I would need a term to annotate R-loop disassembly Thanks Sylvain

Category: Process Definition: A R-loop disassembly process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisting of an RNA:DNA heteroduplex and a “looped-out” non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage, mechanisms that resolve R-loops are essential for genome stability.

is_a DNA metabolic process Part_of GO:0006261 DNA-dependent DNA replication Xref. PMID: 28790157

[sylvainpoux]

Hi David, have you progressed on this request? Because I have another protein involved in the same process Thanks Sylvain

[ukemi]

Sorry Sylvain. This one fell off my radar. I'll do it now.

[sylvainpoux]

Thanks! Sylvain

[ValWood]

R-loop disassembly has 2 parents

1) GO:0006259 DNA metabolic process -OK

2) GO:0006261 DNA-dependent DNA replication -needs removing

These are pathogenic legions, obstructions of DNA replication that need removing:

"are common sites of genome instability: they can trigger DSBs through collisions with the transcription or replication machineries or through active processing by nucleotide excision-repair nucleases " they can also directly interfere with DNA repair

[ValWood]

Also, would. "R-loop processing" be a better name for this process (aka DNA double-strand break processing" since these are toxic structures.

This is how they seem to be referred to in publications e.g. pombe PMID: 29622660 T. brucie PMID: 34749530 human PMID: 34039990

[pgaudet]

Changed the label, and moved under GO:0006338 ! chromatin remodeling

I hope this is right @colinlog

Thanks, Pascale

[pgaudet]

• added references PMID:27252122, PMID:33986538