gocentral
commented
20 years ago Logged In: YES user_id=482748
Added the new terms:
GO:0035194 BF RNA-mediated gene silencing
GO:0035195 BF miRNA-mediated gene silencing
GO:0035196 BF miRNA-mediated gene silencing, production of
miRNAs
GO:0035197 BF siRNA binding
GO:0035198 BF miRNA binding
Added the extra relationship: RNA metabolism ; GO:0016070 --%RNA interference, production of guide RNAs ; GO:0030422
and changed microRNA biosynthesis ; GO:0010195 ; synonym:miRNA metabolism to microRNA biosynthesis ; GO:0010195 ; synonym:miRNA biosynthesis
Original comment by: beckyfoulger
I need some new terms to describe miRNA-mediated gene silencing. I don't think this is covered by RNAi, so I suggest adding the following new terms, and a couple of new relationships for existing terms:
posttranscriptional gene silencing ; GO:0016441 --%RNA-mediated gene silencing ; GO:NEW ----%RNA interference ; GO:0016246 ; synonym:RNAi ----%miRNA-mediated gene silencing ; GO:NEW ------<miRNA-mediate gene silencing, production of miRNAs ; GO:NEW
microRNA metabolism ; GO:0010194 --%miRNA-mediate gene silencing, production of miRNAs ; GO:NEW
RNA metabolism ; GO:0016070 --%RNA interference, production of guide RNAs ; GO:0030422 [NEW RELATIONSHIP]
definitions and some new function terms:
RNA-mediated gene silencing ; GO:NEW Gene inactivation (silencing) triggered by small RNAs. PMID:15066283 PMID:15066275
miRNA-mediated gene silencing ; GO:NEW synonym: microRNA-mediated gene silencing Down regulation of gene expression through the action of microRNAs (miRNAs). miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). They act as guides for the miRNA-induced silencing complex (miRISC) and primarily silence genes by blocking the translation of mRNA transcripts into protein. PMID:15066283 PMID:15066275
miRNA-mediate gene silencing, production of miRNAs ; GO:NEW Cleavage of stem-loop RNA precursors (pre-miRNAs) that are encoded within plant and animal genomes into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein. PMID:15066283 PMID:15066275
new term: siRNA binding ; GO:NEW exact synonym: small interfering RNA binding parent: RNA binding ; GO:0003723 def: Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. PMID:15066283 PMID:15066275
new term: miRNA binding ; GO:NEW exact synonym: microRNA binding parent: RNA binding ; GO:0003723 def: Interacting selectively with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. PMID:15066283
See PMID:15066283 Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell. 2004 Apr 2;117(1):69-81.
See PMID:15066275 Dicers at RISC; the mechanism of RNAi. Cell. 2004 Apr 2;117(1):1-3. Review.
Any comments are welcome. If there's no objections I'll make these new terms on Monday July 12th.
Thanks, Becky
Reported by: beckyfoulger
Original Ticket: "geneontology/ontology-requests/1836":https://sourceforge.net/p/geneontology/ontology-requests/1836