mRNA editing complex (GO:0045293)

[gocentral]

Suggestion on mRNA editing complex (GO:0045293)

I think there should be two instances of this term one for plastid and another for mitochondria.

I am not sure about the third instance if its a complex, which may be a part of nuclear mRNA editing.

-Pankaj

Reported by: jaiswalp

Original Ticket: "geneontology/ontology-requests/1863":https://sourceforge.net/p/geneontology/ontology-requests/1863

[gocentral]

Logged In: YES user_id=735846

Hi Pankaj,

Do you know what the subunits are in these complexes? We'd need to say what they are in the def. It would be especially helpful to know the differences in subunit composition of the two different types that you're asking for.

Thanks,

Jen

Original comment by: jenclark

[gocentral]

Logged In: YES user_id=561361

In Trypanosoma where it was first identified, they have much finer info REf: http://embojournal.npgjournals.com/cgi/content/abstract/11/12/4429 PMID: 1330537 and PMID: 12649499

The people have reported the mechanism in plants but they are still workning on isolating the editing machinery. In most cases it is known that biochemical process involves cytidine deamination.

Since plastid and mito are two different organelles I would not put a generic term mRNA editing complex (GO:0045293) underneath them, because annotations will create problem. We should have two new terms

mitochondrial mRNA editing complex plastid mRNA complex

Right now anything annotated to mRNA editing complex (GO:0045293) e.g. from trypanosoma will appear under plastids as well, which is not good.

For more info http://www.ejbiotechnology.info/content/vol1/issue1/full/4/

For nuclear mRNA editing please consult articl;es from Brenda Bass. She is an expert on this

Couple of her reviews are

Bass, B. L. (1995) An I for editing. Current Biology 5: 598-600.

Bass, B. L. (1997) RNA editing and hypermutation by adenosine deamination. Trends in Biochemical Sciences 22: 157-162.

I hope this will help

Pankaj

Original comment by: jaiswalp

[gocentral]

Logged In: YES user_id=735846

Hi Pankaj,

Yes I see what you mean. This term violates the rule that any single term may only have one part_of parent. It currently has the parents plastid and mitochondrion.

This will be very quick to solve once we can work out the components of the complexes.

Jen

Original comment by: jenclark

[gocentral]

Logged In: YES user_id=436423

Actually, we don't need to know the subunit composition of a complex to have a term. (If we do, great, we'll include it, but if not, it's not usually a problem).

I've moved GO:0045293 up one level, and added two child terms: mitochondrial mRNA editing complex ; GO:0031019 plastid mRNA editing complex ; GO:0031020.

Original comment by: mah11

[gocentral]

• assigned_to: nobody --> gomidori
• status: open --> closed-fixed

Original comment by: mah11