cell competition

[gocentral]

I'd like to add the following new term:

cell growth and/or maintenance ; GO:0008151 --%cell competition ; GO:NEW

cell competition ; GO:NEW Competitive interactions within multicellular organisims betweeen cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells. PMID:1116643 PMID:1506628

(required for Chihiro to curate FBrf0174444 and FBrf0174445).

I'll add it in on Wed 28th July, if there's no objections.

thanks, Becky

Reported by: beckyfoulger

Original Ticket: "geneontology/ontology-requests/1870":https://sourceforge.net/p/geneontology/ontology-requests/1870

[gocentral]

Logged In: YES user_id=451873

I wonder if we could make the term name so that it couldn't be confused with competition between bacteria. And maybe it might make sense to make this a child of development, as I'm presuming that's when this rocess occurs?

Original comment by: jl242

[gocentral]

Logged In: YES user_id=482748

I can add 'sensu Eukarya' to the text string so unicellular organisms don't use it.

Yep it does occur during development- I was thinking of adding it as a child of regulation of growth since cell competition is a way of regulating organ size etc. Then it will be under development too. So I'll make the following relationship:

regulation of growth ; GO:0040008 --<cell competition [sensu Eukarya] ; GO:NEW

Original comment by: beckyfoulger

[gocentral]

Logged In: YES user_id=451873

The problem with using 'sensu Eukarya' is that it doesn't exclude yeast (which I'm sure undergoes competition too)...it's really unicellular v/s multicellular that we'd need to distinguish between (is there a sensu that would work for that?).

We couldn't really have 'organismal cell competition' though, because 'cellular cell competition' doesn't make sense! What about 'cell competition during development'? I'm not sure about a parent term though, would a generic 'cell competition' term make sense?

Original comment by: jl242

[gocentral]

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very true- so rethinking, 'sensu Metazoa' would probably work best here- according to the NCBI taxonomy browser the kingdom Metazoa has the common name: multicellular animals.

I'm not sure a generic 'cell competition' term would make sense, since I think the process of cell competition in size control is very distinct, and probably not similar to cell competition in yeast, bacteria etc. (though Val or someone from SGD could probably say more). So for the moment I'd just be tempted to add the 1 new term:

regulation of growth ; GO:0040008 --<cell competition (sensu Metazoa) ; GO:NEW

cell growth and/or maintenance ; GO:0008151 --%cell competition (sensu Metazoa) ; GO:NEW

what do you think?

Original comment by: beckyfoulger

[gocentral]

Logged In: YES user_id=451873

Yes, that should be okay.

Original comment by: jl242

[gocentral]

• assigned_to: nobody --> beckyfoulger

Original comment by: beckyfoulger

[gocentral]

Logged In: YES user_id=482748

Added the new term: cell competition (sensu Metazoa) ; GO:0035212

Competitive interactions within multicellular organisims betweeen cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells. As in, but not restricted to, animals (Metazoa, ncbi_taxonomy_id:33208). PMID:1116643 PMID:1506628 FB:bf

regulation of growth ; GO:0040008 --<cell competition (sensu Metazoa) ; GO:0035212 (NEW)

cell growth and/or maintenance ; GO:0008151 --%cell competition (sensu Metazoa) ; GO:0035212 (NEW)

Original comment by: beckyfoulger

[gocentral]

• status: open --> closed-accepted

Original comment by: beckyfoulger