pgaudet
commented
4 years ago - GO:0044607 disruption by symbiont of host endothelial cells should be obsoleted and use an extension -> see #18721
Closed ValWood closed 4 years ago
pgaudet
commented
4 years ago pgaudet
commented
4 years ago Points 1, 3 and 4 -> see ticket #18719 Point 2: see ticket #18720
In most of these terms, the word "disruption" is used in lots of different contexts
1.
GO:0044004 disruption by symbiont of host cell Definition (GO:0044004 GONUTS page) Any process in which an organism has a negative effect on the functioning of the host's cells. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2.
(1 annotation, phenotype?)
3.
4. GO:0044661 disruption by virus of host cell has a lot of annotations but some of the children look dubious
[ ] . For example GO:0098932 disruption by virus of host cell wall peptidoglycan during virus entry -> degradation of host cell wall peptidoglycan during virus entry?
[ ] Definition (GO:0098932 GONUTS page) A process carried out by a virus that breaks down peptidoglycans in the cell wall of its host during viral entry. Seems that the parentage of "viral entry into host" would be sufficient?
[ ] GO:0044662 disruption by virus of host cell membrane A process by which a virus has a negative effect on the functioning of a host cellular membrane.
I don't understand this one at all what is "negative effect on the functioning of a host cellular membrane"? 5 annotations CACAO but looking at the paper it should probably merge into
GO:0044659 cytolysis by virus of host cell Definition (GO:0044659 GONUTS page) The killing by a virus of a cell by means of the rupture of cell membranes and the loss of cytoplasm. PMID:26728778
it's another way of saying the same thing
i.e I think most of the high level "disruption terms" can be removed as most of the meaningful terms have alternative sensible parents...
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