NTR: DNA-binding transcription activator activity, RNA polymerase I-specific

[ValWood]

A protein, or a member of a complex, or a non-coding RNA that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase I-transcribed gene to activate or increase transcription.

[mah11]

That def reads like the description of a gene product rather than an activity.

I think the same of the existing def for GO:0001228, although the parent (GO:0001216) def is OK.

[ValWood]

I copied it from the DNA-binding transcription activator activity, RNA polymerase II-specific

so they probably need revising to the parent

[colinlog]

for GO:00003700, DNA-binding transcription factor activity

Would the definition written as below be more acceptable with respect to this being an activity rather than a bio-entity? It is mr ein line with the definition of GO:0001216, which concerns only activators, whilst GO:0003700 covers also repressors GO:0001217

@mah11 @pgaudet @ValWood .. Interacting selectively and non-covalently with a DNA sequence (sometimes referred to as a motif) within a cis-regulatory region of a gene in order to modulate the frequency, rate or extent of transcription by a RNA polymerase. The activity can be performed by a protein, an RNA or a multimolecular complex. Cis-regulatory DNA regions include promoters (proximal and distal), enhancers, silencers, insulators and boundaries. Genes are transcription units and include bacterial operons. ..

[mah11]

@colinlog yes, exactly

[pgaudet]

@ValWood What would be the reference for this ? I see you have closed the pombase ticket (https://github.com/pombase/curation/issues/2619) and annotated this as a GTF. Close ?

[ValWood]

Yes, there was a later discussion https://github.com/pombase/curation/issues/2619#issuecomment-700855980