hepoxilin A(3) synthase activity

[gocentral]

Hi

I am trying to find the correct GO term to describe the function of hepoxilin A(3) synthase activity

Is GO:0047977 hepoxilin-epoxide hydrolase activity the correct term to use..

Some information can be found here:PMID:15123652

Hepoxilins form a family of eicosanoids that are biosynthesized via the 12S-lipoxygenase (12S-LOX)1 pathway of the arachidonic acid (AA) cascade. Chemically they constitute epoxy-hydroxy eicosanoids that can be classified as HxA3 (8-hydroxy-11,12- epoxyeicosatetraenoic acid) and HxB3 (10-hydroxy- 11,12-epoxyeicosatrienoic acid) (1). Hepoxilins exhibit a myriad of biological activities. They stimulate glucose- induced secretion of insulin and increase the intracellular calcium levels in rat pancreatic islets cells (2). In human neutrophils a dose-dependent increase in intracellular calcium concentration (3, 4) and an augmented cellular diacylglycerol content (5) were observed. The latter effect was blocked by pertussis toxin, suggesting a receptor-mediated mechanism involving GTP-binding proteins. In neurons, HxA3 induces hyperpolarization of the membrane potential and increases the amplitude and duration of the inhibitory postsynaptic potential (6, 7). In platelets and aplysia neurons, HxA3 antagonized the expansion of cell volume and the opening of potassium channels (8, 9).

cheers Evelyn

Reported by: ecamon

Original Ticket: "geneontology/ontology-requests/1935":https://sourceforge.net/p/geneontology/ontology-requests/1935

[gocentral]

• priority: 5 --> 9

Original comment by: ecamon

[gocentral]

Logged In: YES user_id=463625

Sorry...same paper...

please may a I have: 'hepoxilin biosynthesis' as a child of 'icosanoid biosynthesis' GO:0046456

Hepoxilins are bioactive 'eicosanoids' that have ...

More research is obviously needed to work out the mechanisms involved in 'hepoxilin biosynthesis'...

Q02759 cheers Ev

Original comment by: ecamon

[gocentral]

• assigned_to: nobody --> girlwithglasses

Original comment by: girlwithglasses

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Logged In: YES user_id=473796

Hi Ev,

The enzyme activity can be captured using GO:0050473, arachidonate 15-lipoxygenase activity, and a new term, hepoxilin A3 synthase activity ; GO:0051120.

Also added hepoxilin metabolism ; GO:0051121 hepoxilin biosynthesis ; GO:0051122

Original comment by: girlwithglasses

[gocentral]

• milestone: --> TermGenie
• status: open --> closed-accepted

Original comment by: girlwithglasses

[gocentral]

• priority: 9 --> 5

Original comment by: mah11