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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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Obsolete:PMA-inducible membrane protein ectodomain proteolysis? #19855

Closed hattrill closed 4 years ago

hattrill commented 4 years ago

Came across this term that seems to describe an experimental condiition rather than a GO BP:

PMA-inducible membrane protein ectodomain proteolysis GO:0051088

'The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist.'

Only 7 exp annotations, all to Adam proteases from BHF-UCL (tagging @RLovering) plus ~95 manual (inc IBAs, TAS, ISO)

Think that they could all be merged into the parent term 'membrane protein ectodomain proteolysis'.

pgaudet commented 4 years ago

Right ! At least the paper cited should be annotated to 'cytokine processing'.

@RLovering are you OK with obsoletion and reannotation ?

Thanks, Pascale

RLovering commented 4 years ago

yes, have updated annotations and agree with removing this term Thanks for asking Ruth

pgaudet commented 4 years ago

Dear all,

The proposal has been made to obsolete 'GO:0051088 PMA-inducible membrane protein ectodomain proteolysis'. The reason for obsoletion is that this represents an assay to induce PKC (https://en.wikipedia.org/wiki/12-O-Tetradecanoylphorbol-13-acetate). The EXP annotations have been removed. There are no mappings to this term; this term is not present in any subsets.

Comments can be added to the ticket: : https://github.com/geneontology/go-ontology/issues/19503

Thanks, Pascale