search

geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
Creative Commons Attribution 4.0 International
222 stars 40 forks source link

Remove EC:2.3.1.5 from GO:0008080 #20072

Closed sjm41 closed 4 years ago

sjm41 commented 4 years ago

Please remove EC:2.3.1.5 as an xref from this term: id: GO:0008080 name: N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.5

EC:2.3.1.5 is specifically for Arylamine acetylase (https://enzyme.expasy.org/EC/2.3.1.5) and it's already correctly an xref of GO:0004060 (arylamine N-acetyltransferase activity).

hdrabkin commented 4 years ago

In trying to find a suitable reference for GO:0008080, it turns out the literature contributing to the confusion

N-Acetyltransferases (E.C. 2.3.1.5) catalyze the acetylation of arylamines (Mont R. Juchau, Hao Chen, in Handbook of Developmental Neurotoxicology, 1998) See also https://en.wikipedia.org/wiki/N-acetyltransferase Need to see if there are any N-acetyltranferases that do not use arylamines, (arylhydroxylamines and arylhydrazines.) A term merge might be needed, OR the intended use of GO:0008080 was to be a parent to GO:0004060 for arylamine, assuming sibs (but actually same enzyme, but different substrates IE, acetyl-CoA + an arylamine = an N-acetylarylamine + CoA Cross reference: EC 2.3.1.5 | RHEA:16614 (already a child of GO:0008080) then acetyl-CoA + an arylhdroxylamine = N-acetylarylhdroxylamine + CoA (GO new, RHEA new) and acetyl-CoA + an arylhydrazines = N-acetylarylhydrazines+ CoA (GO new2, RHEA new2)

hdrabkin commented 4 years ago

SO GO:0008080 already has several children,, meant as a grouping term. But the literature keeps calling the EC number by N-Acetyltransferase, when in fact the EC specifically names it arylamine N-acetyltransferase. ARGH. Removing xref.

sjm41 commented 4 years ago

Quick work! Thanks.