search

geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
Creative Commons Attribution 4.0 International
223 stars 40 forks source link

NTR: nuclear corepressor activity #20262

Closed pgaudet closed 4 years ago

pgaudet commented 4 years ago

This term is missing. It is similar to transcription corepressor activity.

To be completed with @colinlog

pgaudet commented 4 years ago

Definition: A transcription coregulator activity that represses or decreases the transcription of specific gene sets via selective and non-covalent binding to a DNA-bound nuclear receptor. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.

pgaudet commented 4 years ago

PMID: 7566114 PMID: 7566126

pgaudet commented 4 years ago

+id: GO:0140536 +name: nuclear corepressor activity +namespace: molecular_function +def: "A transcription corepressor activity that represses or decreases the transcription of specific gene sets via selective and non-covalent binding to a DNA-bound nuclear receptor. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators." [PMID:7566114, PMID:7566126, PMID:9238851] +comment: Curator guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity. +is_a: GO:0003714 ! transcription corepressor activity +relationship: part_of GO:0000122 ! negative regulation of transcription by RNA polymerase II +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/20262 xsd:anyURI +created_by: pg +creation_date: 2020-11-03T13:02:08Z

ValWood commented 4 years ago

did you mean to say " transcription corepressors " in the definition rather then "nuclear corepressor" in these 2 instances For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators."

ValWood commented 4 years ago

Also would "nuclear receptor corepressor" be a better term label?

I didn't know about these and I would immediately think this term just referred to a. nuclear version of a bog-standard corepressor.

pgaudet commented 4 years ago

Also would "nuclear receptor corepressor" be a better term label?

yes ok

pgaudet commented 4 years ago

Also changed nuclear receptor transcription coactivator activity -> nuclear receptor coactivator activity

pgaudet commented 4 years ago

Edited definition to "A transcription corepressor activity that represses or decreases the transcription of specific gene sets via selective and non-covalent binding to a DNA-bound nuclear receptor. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators."

Thanks, Pascale