MF in BP ontology

[ValWood]

GO:0052054 negative regulation by symbiont of host peptidase activity

Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction.

this should be GO:0004866 endopeptidase inhibitor activity

has one annotation https://www.uniprot.org/uniprot/Q6PQH2 (this IDA annotation could just be moved to the appropriate function term, currently provided by a KW mapping)

[ValWood]

from comment Secreted effector that interacts with and inhibits the pathogenesis-related P69B subtilisin-like serine protease of host tomato (PubMed:15096512). Inhibition of host proteases by a pathogen extracellular protease inhibitor forms a specific type of defense-counterdefense mechanism between plants and microbial pathogens (PubMed:15096512).1 Publication

the process should be GO:0140415 effector-mediated modulation of host defenses by symbiont

[pgaudet]

This applies to the whole branch - GO:0052148 modulation by symbiont of host catalytic activity or even GO:0052055 modulation by symbiont of host molecular function

Maybe we can look at this together on a future call ?

[ValWood]

Yes. At PHI-base we have been annotating these as:

x inhibitor activity involved_in effector-mediated blah (usually immune but sometimes other processes)

[ValWood]

Ah I see that is what I said above...

[pgaudet]

We need to review the entire branch, GO:0052055 modulation by symbiont of host molecular function this, but that involves reviewing the virus keywords

@pmasson55 - can you help ?

[pgaudet]

Discussing with @pmasson55

The Keywords have a hierarchy, for example like this part:

• Inhibition of host interferon signaling pathway by virus (KW-1114)

• • mapped to GO suppression by virus of host type I interferon-mediated signaling pathway (GO:0039502)

• children include:

• • Inhibition of host STAT1 by virus (KW-1105) -> mapped to 'suppression by virus of host STAT1 activity' (GO:0039563)
• • Inhibition of host STAT2 by virus (KW-1106) -> mapped to 'suppression by virus of host STAT2 activity' (GO:0039564)
• • Inhibition of host TYK2 by virus (etc)
• • Modulation of host PP1 activity by virus etc

• Note that mappings to parent terms are applied to each entry, so that an entry with KW-1105 will get both GO:0039563 and GO:0039502

• We could change the mapping for the 'inhibitors of activity', like KW-1105, to 'transcription factor inhibitor activity', however if we do that we loose which transcription factor is inhibited when we do mappings (we can capture those are extensions and inputs in P2GO and GO-CAMs, but any propagations loose it).

• We could nevertheless move the terms to MF, for example 'STAT1 transcription factor inhibitor activity' - however our guidelines state that we don't want to capture gene products in the term.

@cmungall @ValWood @thomaspd thoughts ?

Thanks, Pascale

[ValWood]

@pgaudet I think this has been done by another route?

[pgaudet]

Right ! Closed in #21740

Thanks