GO:0034515 proteasome storage granule - complex?

[hattrill]

'proteasome storage granule' GO:0034515 is classed as a 'protein-containing complex' as it is a child of 'cytosolic proteasome complex'

But it seems to be just either a clump of inactive proteosome SUs and/or be a bit like a stress granule (rather than a complex, as we'd expect a complex to be capable of an MF)

('protein-containing complex': A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.)

Refs: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771618/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582879/

It's more of a yeast thing - so perhaps @ValWood @srengel have some opinions, but it is being propagated by PAINT @pgaudet from PANTHER:PTN000101661, so is now on the fly radar:

Rather than a protein-containing complex, perhaps it is better as:

is_a intracellular non-membrane-bounded organelle part_of cytoplasm

or just part_of cytoplasm

[ValWood]

I agree.

[krchristie]

This paper agrees that the PSG is a membrane-less organelle:

Marshall RS, Vierstra RD. To save or degrade: balancing proteasome homeostasis to maximize cell survival. Autophagy. 2018;14(11):2029-2031. doi:10.1080/15548627.2018.1515531. Epub 2018 Sep 11. PMID:30204036

How membrane-less organelles such as PSGs isolate themselves from the surrounding cytoplasmic milieu is unclear,

It also doesn't make sense to me to have a PSG as is_a proteasome complex when it's not a type of active proteasome complex.

I also changed all of the synonyms using the PSG acronym to be related, rather than exact, to be consistent with our current practice to make all synonyms using acronyms be related rather than exact to avoid issues if the same acronym has multiple meanings.

[hattrill]

Thanks, @krchristie