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Source ontology files for the Gene Ontology
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Q:adding ethanolaminephosphate to the second mannose #2041

Closed gocentral closed 9 years ago

gocentral commented 20 years ago

what activity should I use for

"adding ethanolaminephosphate to the second mannose in the biosynthesis of glycosylphosphatidylinositol (GPI)"

PMID: 15452134

I can't find anything appropriate when I search with "ethanolamine"

val

Reported by: ValWood

Original Ticket: "geneontology/ontology-requests/2048":https://sourceforge.net/p/geneontology/ontology-requests/2048

gocentral commented 20 years ago

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can you tell which step it is in this diagram?

http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/inositol/ GlcNPtdIns.html

Original comment by: mah11

gocentral commented 20 years ago

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Matthew Berriman wrote: > > I would go for "phosphoethanolamine transferase activity" as a function, > which will need a new GO term. > > Matt

Original comment by: ValWood

gocentral commented 20 years ago

Original comment by: girlwithglasses

gocentral commented 19 years ago

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If you read the article at http://www.jbc.org/cgi/content/full/279/19/ 19614 (PMID:14985347), they refer to this activity as 'EtN-P transferase', so I propose calling the term something like 'mannose-ethanolamine phosphotransferase activity'. We can give it plenty of synonyms for ease of searching.

Proposed def: Catalysis of the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2. The reaction is: ethanolamine phosphate (EtN-P) + Man-alpha-(1,2)-Man-alpha-(1,2)- Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man- alpha-(1,6)-R, where R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid.

Is that OK?

Original comment by: girlwithglasses

gocentral commented 19 years ago

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yep

reminder gpi7

Original comment by: ValWood

gocentral commented 19 years ago

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OK, it has been added: GO:0051267 - mannose-ethanolamine phosphotransferase activity

I've put gpi7 activity as a synonym for you.

Original comment by: girlwithglasses

gocentral commented 19 years ago

Original comment by: girlwithglasses

gocentral commented 19 years ago

Logged In: YES user_id=516865

that was to remind me which gene it was ;)

what is the GO ID?

Original comment by: ValWood

gocentral commented 13 years ago

Original comment by: mah11