Merge 'Chromatin Accessibility Complex' with 'ISW2 Complex'

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GO:0008623 Chromatin Accessibility Complex should be merged with: GO:0016588 ISW2 complex

They are the same thing. I would suggest making "ISW2 complex" a synonym of "Chromatin Accessibility Complex"

Here are a couple of references:

Poot, R. A., G. Dellaire, B. B. H|lsmann, M. A. Grimaldi, D. F. V. Corona, P. B. Becker, W. A. Bickmore, and P. D. Varga-Weisz. 2000. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. EMBO J. 19:3377-3387 PMID: 10880450

Mol Cell Biol. 2004 Jan;24(1):217-27. Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Iida T, Araki H. PMID: 14673157

Thanks, Jodi

Reported by: jodih

Original Ticket: "geneontology/ontology-requests/2067":https://sourceforge.net/p/geneontology/ontology-requests/2067

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• milestone: --> TermGenie
• assigned_to: nobody --> jl242

Original comment by: jl242

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Hi,

can the term name be chromatin accessibility complex, and ISW2 complex be a narrower then synonym? chromatin accessibility complex sounds more like a grouping term like 'chromatin remodelling complex'. I have nothing annotated to chromatin accessibility complex at the moment but I'm sure I will, however S. pombe doesn't have ISW2 or ISW2 equivalents, (seems to be a lineage specific gene loss).

val

Original comment by: ValWood

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Hi Val - I think that's what Jodi was suggesting isn't it?

Original comment by: jl242

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yes except they aren't completely equivalent so it my be preferred to make ISW2 complex a child term?

Original comment by: ValWood

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Hi,

I don't know much about CHRAC (chromatin accessibility complex) but from my reading it doesn't seem like a grouping term. It's a type of chromatin remodelling complex that contains an ISW-type of nucleosome- dependent ATPase. For example, the beginning of this abstract from PMID 10880450 says:

Chromatin remodelling complexes containing the nucleosome-dependent ATPase ISWI were first isolated from Drosophila embryos (NURF, CHRAC and ACF). ISWI was the only common component reported in these complexes. Our purification of human CHRAC (HuCHRAC) shows that ISWI chromatin remodelling complexes can have a conserved subunit composition in completely different cell types, suggesting a conserved function of ISWI.

Jodi

Original comment by: jodih

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Don't need to have exactly the same meaning to merge - as long as all transferred annotations will still be correct...

Original comment by: jl242

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The transferred annotations for S. cerevisiae are correct. I don't know if ISW2 complex has been used in annotation for other organisms, as the term was added so recently.

Original comment by: jodih

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ok, my mistake. i'll holler if I have a problem with it later

Original comment by: ValWood

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Okay, done.

Original comment by: jl242

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• status: open --> closed-accepted

Original comment by: jl242