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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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GO:0045730 respiratory burst #20638

Closed ValWood closed 3 years ago

ValWood commented 3 years ago

This sounds like a phenotype, or a combination of process and outcome (i.e positive regulation of respiration + production of free radicals (only has 32 annotations). Should it exist?

GO:0045730 respiratory burst

Definition (GO:0045730) A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.

addiehl commented 3 years ago

GO:0045730 respiratory burst refers to the regulated production of reactive oxygen species involved in defense responses in both animals and plants, as well as cell signaling and other processes. https://en.wikipedia.org/wiki/Respiratory_burst

The child term, GO:0002679 respiratory burst involved in defense response represents an essential process of the innate immune system. The respiratory burst is used a defensive mechanism in neutrophils and other leukocytes, used to kill bacteria and other pathogens via the production of reactive oxygen species. This is a very well studied process. https://pubmed.ncbi.nlm.nih.gov/27558335/ https://pubmed.ncbi.nlm.nih.gov/19224236/ https://pubmed.ncbi.nlm.nih.gov/10618505/

ValWood commented 3 years ago

Yes that makes sense, we use it for plants too. I think I was confused by the grouping but it is also used in non defense contexts.