Closed Kawatebi closed 3 years ago
Hello @Kawatebi
Do you annotate toxins ? Normally GO annotates gene products, so apamin would be out of scope (as far as I can tell it's not encoded by a gene?).
Thanks, Pascale
Hi @pgaudet
Apamin is a peptide found in bee venom https://www.uniprot.org/uniprot/P01500 and here is the mRNA sequence https://www.ebi.ac.uk/ena/browser/view/AAB34402
Cheers, Kate
Great, thanks!
+[Term] +id: GO:0140628 +name: outward rectifier potassium channel inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel." [PMID:28108814] +is_a: GO:0019870 ! potassium channel inhibitor activity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/21157 xsd:anyURI +created_by: pg +creation_date: 2021-03-24T07:58:39Z
@pgaudet
Fantastic thanks
Hello,
I would like to request the term 'outward rectifier potassium channel inhibitor activity' based on PMID: 28108814.
The authors report, the inhibition of a voltage-dependent outwardly rectifying potassium channel Kv1.3 by the toxin apamin (Figure 1).
Definition:
Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel.
Let me know if you require any more information.
Many thanks,
Kate