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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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NTR: "Outward rectifier potassium channel inhibitor activity" #21157

Closed Kawatebi closed 3 years ago

Kawatebi commented 3 years ago

Hello,

I would like to request the term 'outward rectifier potassium channel inhibitor activity' based on PMID: 28108814.

The authors report, the inhibition of a voltage-dependent outwardly rectifying potassium channel Kv1.3 by the toxin apamin (Figure 1).

Definition:

Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel.

Let me know if you require any more information.

Many thanks,

Kate

pgaudet commented 3 years ago

Hello @Kawatebi

Do you annotate toxins ? Normally GO annotates gene products, so apamin would be out of scope (as far as I can tell it's not encoded by a gene?).

Thanks, Pascale

Kawatebi commented 3 years ago

Hi @pgaudet

Apamin is a peptide found in bee venom https://www.uniprot.org/uniprot/P01500 and here is the mRNA sequence https://www.ebi.ac.uk/ena/browser/view/AAB34402

Cheers, Kate

pgaudet commented 3 years ago

Great, thanks!

pgaudet commented 3 years ago

+[Term] +id: GO:0140628 +name: outward rectifier potassium channel inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel." [PMID:28108814] +is_a: GO:0019870 ! potassium channel inhibitor activity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/21157 xsd:anyURI +created_by: pg +creation_date: 2021-03-24T07:58:39Z

Kawatebi commented 3 years ago

@pgaudet

Fantastic thanks