NTR:dpCoA-cap decapping

[SHS111]

Hello, i would like to propose a new term dpCoA-cap decapping Definition : Cleavage of the dpCoA-cap of an RNA It should be the child term of GO:0110154 RNA decapping References are PubMed=32374864 & PubMed=32432673 Thanks Shyamala Sundaram

[SHS111]

hello, Just wanted to know if this term would be available soon. Thank you & Best Regards Shyamala

[pgaudet]

Hi @SHS111

What do you think if we made this a molecular function (and the sibling term you requested in #21408) , to match 'NAD-cap (NAD-forming) hydrolase activity' (requested in #17594)?

I would like to have your input on this (and maybe that of @sylvainpoux as he requested the other terms) - but based on the papers you quote, it seems like RA capping/decapping mediates RNA stability/degradation, initiation, quality control, etc. All these processes are currently missing in the ontology - for example we could probably add 'methylguanosine-cap decapping' part of 'nuclear-transcribed mRNA catabolic process'

Thanks, Pascale

[sylvainpoux]

Hi Pascale and Shyamala (@SHS111),

I thing it makes sense to create Molecular Function terms as all reactions correspond to Rhea reactions (NAD, FAD etc.).

Regarding the Process, a generic term describing RNA capping makes sense, but it would be important to separate them from the classical methylguanosine-cap.

Thanks

Sylvain

[SHS111]

Hi Pascale and Sylvain, It would be a good idea to create a molecular function (and the sibling term requested in #21408https://github.com/geneontology/go-ontology/issues/21408) , to match 'NAD-cap (NAD-forming) hydrolase activity' (requested in #17594https://github.com/geneontology/go-ontology/issues/17594) Thanks & Best Regards Shyamala

[ValWood]

This should be linked with this work? https://github.com/geneontology/go-ontology/issues/24892

[ValWood]

correction this is the decapping ticket https://github.com/geneontology/go-ontology/issues/24919

[edwong57]

Related to #21408, which needs discussion