Obsoletion with direct replacement (merge equivalent) : [meiotic sister chromatid cohesion, centromeric/meiotic centromeric cohesion protection]

[ValWood]

Term to be merged I think there is really no difference between these 2 terms (both were requested by me but are used by others):

meiotic sister chromatid cohesion, centromeric The cell cycle process in which centromeres of sister chromatids are joined during meiosis.

meiotic centromeric cohesion protection The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation after cohesin is cleaved by separase along the arm regions.

Reason for merge meiotic sister chromatid cohesion, centromeric is not different from normal meiotic cohesion, the difference is that in meiosis I cohesion is removed from the chromosome arms, but retained at the centromeres , so

meiotic sister chromatid cohesion, centromeric is really the 'inverse' of meiotic centromeric cohesion protection the cohesin is not protected, so it remains. They are 2 ways of saying the same thing.

Any other information

Need to improve definition.

Annotations Pombase 8 (all are protection) Flybase 6 Uniprot 1 TAIR 2 SGD1 MGI 4

do you agree with this merge? @srengel @hattrill @sjm41 @tberardini @ukemi

[ValWood]

Most of the annotated genes seem oK to be 'protection'

If it helps this is what I have for this pathway

SPBC106.01 | mph1 | dual specificity protein kinase Mph1 SPAC15E1.07c | moa1 | meiosis-specific kinetochore regulator (Meikin) Moa1 SPBP35G2.03c | sgo1 | meiotic cohesin protection protein, shugoshin, Sgo1 SPCC1322.12c | bub1 | mitotic spindle checkpoint kinase Bub1 SPCC1020.02 | spc7 | NMS complex subunit, Spc105/KNL-1 family member, blinkin, Spc7 SPAC23C11.16 | plo1 | Polo kinase Plo1 SPAC823.15 | ppa1 | serine/threonine protein phosphatase PP2A catalytic subunit Ppa1 SPBC16H5.07c | ppa2 | serine/threonine protein phosphatase PP2A catalytic subunit Ppa2 SPCC188.02 | par1 | serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par1 SPAP8A3.09c | paa1 | serine/threonine protein phosphatase PP2A scaffold subunit Paa1

[ValWood]

Hmm, this term could also merge couldn't it:

maintenance of meiotic sister chromatid cohesion, centromeric (GO:0035875) The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle.

[ValWood]

ACTION

How it looks:

This is way too many terms, my fault because I didn't understand this when I first began annotating this and requesting terms. I'll describe the proposed clean up below.

[ValWood]

keep GO:1990813 meiotic centromeric cohesion protection in anaphase I which is correctly positioned. Meiotic cohesion is protected at meiotic anaphase I so that the sister chromatids remain together during homologous segregation.

obsolete the other terms, and merge into GO:1990813 meiotic centromeric cohesion protection in anaphase I, or the appropriate regulation children (I can repurpose these)

[ValWood]

GO:2000718 regulation of maintenance of mitotic sister chromatid cohesion, centromeric

i.e one of the annotated papers https://europepmc.org/article/MED/32750047 Haspin is involved in protection of mitotic centromere cohesion by binding to the cohesin-associated protein Pds5 and antagonizing the cohesin unloading factor Wapl [[21]