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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
Creative Commons Attribution 4.0 International
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chromatin remodelling definition #21748

Closed ValWood closed 2 years ago

ValWood commented 3 years ago

GO:0006338 chromatin remodeling has a very broad definition:

Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. 

Is this OK?

ValWood commented 3 years ago

Should the definition mention organization of nucleosomes? to distinguish from more macro changes to chromatin (cohesion, condensation etc). Does 'chromatin remodelling' really include "global changes necessary for chromosome segregation'? If so we should be specific about which ones?

@colinlog

pgaudet commented 3 years ago

Transcription workshop @colinlog @ValWood @RLovering @hattrill

This will be replaced by functions

pgaudet commented 2 years ago

We have decided that this term needs to remain.

ValWood commented 2 years ago

I changed back to my original title which was about the definition rather than it being an MF, but this will probably come up later.

pgaudet commented 2 years ago

Current def: "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation."

We can discuss this tomorrow.

pgaudet commented 2 years ago

Proposed change in definition for chromatin remodeling

Dynamic structural changes to ~eukaryotic~ chromatin ~occurring throughout the cell division cycle~. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, DNA replication, as well as global changes necessary for chromosome segregation.

pgaudet commented 2 years ago

We have not addressed @ValWood 's comment

Should the definition mention organization of nucleosomes? to distinguish from more macro changes to chromatin (cohesion, condensation etc). Does 'chromatin remodelling' really include "global changes necessary for chromosome segregation'? If so we should be specific about which ones?