Closed pgaudet closed 2 years ago
Fix definition " A small RNA-based epigenetic gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism."
Remove 'GO:0016569 covalent chromatin modification' parent from 'GO:0006346 DNA methylation-dependent heterochromatin assembly' Remove has_part GO:0006306 ! DNA methylation Add: has_part GO:0009008 ! DNA-methyltransferase activity
is missing parent 'heterochromatin assembly'
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