geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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Add parent to GO:0080188 gene silencing by RNA-directed DNA methylation #22047

Closed pgaudet closed 2 years ago

pgaudet commented 2 years ago
GO:0080188  gene silencing by RNA-directed DNA methylation 

is missing parent 'heterochromatin assembly'

@colinlog @ValWood transcription workshop discussion

pgaudet commented 2 years ago

Fix definition " A small RNA-based epigenetic gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism."

pgaudet commented 2 years ago
pgaudet commented 2 years ago

Remove 'GO:0016569 covalent chromatin modification' parent from 'GO:0006346 DNA methylation-dependent heterochromatin assembly' Remove has_part GO:0006306 ! DNA methylation Add: has_part GO:0009008 ! DNA-methyltransferase activity