HULC complex parents (TPV)

geneontology / go-ontology

Source ontology files for the Gene Ontology

http://geneontology.org/page/download-ontology

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HULC complex parents (TPV) #22142

Closed ValWood closed 2 years ago

ValWood commented 3 years ago

HULC complex has parent 'heterochromatin' but sometimes it is euchromatin?

Maybe just move up to 'chromatin?'

pgaudet commented 3 years ago

Also removed part_of GO:0005694 ! chromosome (redundant) and GO:0000151 ! ubiquitin ligase complex, since it was is_a GO:0031371 ! ubiquitin conjugating enzyme complex, and is defined as a ubiquitin conjugating enzyme complex.

Thanks, Pascale

ValWood commented 3 years ago

It is actually a ubiquitin ligase though. All ubiquitin ligase complexes also include a ubiquitin conjugating enzyme, but should be described as ubiquitin ligases . So the HULC def should be revised to ligase.

ValWood commented 3 years ago

GO:0033503 JSON HULC complex Cellular Component

Definition (GO:0033503 GONUTS page) A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2. PMID:17363370

the subunits are incorrect. Should be In Schizosaccharomyces the subunits are Rhp6, Shf1, Brl2/Rfp1 and Brl1/Rfp2

pgaudet commented 2 years ago

[x] Changed def to ""A ubiquitin ligase complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp6, Shf1, Brl2/Rfp1 and Brl1/Rfp2.
[x] added back parent 'ubiquitin ligase complex', since the def states that it contains both a ubiquitin ligase and a ubiquitin conjugating enzyme; is this OK ?

ValWood commented 2 years ago

Sounds good.