relabel "cell cycle switching, mitotic to meiotic cell cycle" and children

[ValWood]

cycle switching, mitotic to meiotic cell cycle

could this be relabelled as "meiotic commitment" as this seems to be what it is usually referred to? Nobody calls it "cell cycle switching, mitotic to meiotic cell cycle"

Also there is a descendant term signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle but this IS a signalling even so I wonder if their term is required? or are there additional parts to the process (I can't think what they would be because a switch is a signalling event?)

@Antonialock does this sound reasonable?

[pgaudet]

"signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle" is only used by pombase

likewise for the 3 regulation terms:

• GO:0110045 negative regulation of cell cycle switching, mitotic to meiotic cell cycle
• GO:0140648 positive regulation of cell cycle switching, mitotic to meiotic cell cycle
• GO:0110044 regulation of cell cycle switching, mitotic to meiotic cell cycle

should we obsolete and replace by the parent?

[Antonialock]

probably!

I only used that term for the lack of a better one. we discussed this before and could never think of a replacement term.

Meiotic commitment sounds fine. I agree, it’s not a “Switching” event since once you are committed to meiosis you can’t switch back. It is unidirectional, a commitment. A bit like a transition in a way perhaps?

I had a quick look yesterday and I think there were 4 genes annotated to the switching term that were not also annoyed to ‘signal transduction’ -perhaps just have a quick check of those to see they would be ok?

[ValWood]

I have been looking at papers recently and they all called this signalling pathway "commitment " so I think we agree that 'commmitment' is a better label.

Is it all signalling?

These are the. genes not annotated to signalling:

SPAC17C9.01c | nuc2 | anaphase-promoting complex TPR lobe subcomplex subunit Apc3 SPBC16G5.15c | fkh2 | DNA-binding forkhead transcription factor Fkh2 SPBC19F5.01c | puc1 | G1 cyclin Puc1 SPBC1718.07c | zfs1 | zf-CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism

so possibly not. The Zfs1 is an mRNA sequestering thingy, so it is involved in commitment but is it part of the signalling pathway?

Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast. https://www.pombase.org/reference/PMID:29084823

it seems to sequester the RNA of the puc1 cyclin to inhibit the commitment program.