enzyme activity missing relationship

[gocentral]

Hi,

Should 'regulation of enzyme activity' be part of 'enzyme activity' in the same way as 'regulation of development' is part of 'development'?

Thanks,

Jen

Reported by: jenclark

Original Ticket: "geneontology/ontology-requests/2339":https://sourceforge.net/p/geneontology/ontology-requests/2339

[gocentral]

Logged In: YES user_id=436423

Not at present, because 'regulation of enzyme activity' is a process term, whereas 'enzyme activity' is a synonym of 'catalytic activity', which is a function term. We don't yet have any way to make relationships metween terms from different ontologies, and it may still be some time before we do.

m

Original comment by: mah11

[gocentral]

Logged In: YES user_id=735846

Cool. Are these two terms in different ontologies on purpose then or is that something that is likely to change at some point?

Thanks,

Jen

Original comment by: jenclark

[gocentral]

• status: open --> closed

Original comment by: girlwithglasses

[gocentral]

Logged In: YES user_id=473796

I guess that you understand why 'catalytic activity' is in function. Regulation in general is considered to be a process since there's frequently more than one step involved and a regulator does not need to interact directly with its target for regulation to occur: there may be numerous intermediate molecules or targets. For example, enzyme A might act as a regulator of function B in a number of ways; it could interact directly with the protein that performs B, altering the conformation so that the protein can no longer perform B; A could alter the concentration of the substrates for function B; A could produce an inhibitor or an activator of the protein that performs B; A might be a receptor which binds a ligand, which then sets off a signalling cascade that ends with the activation of function B. A is regulating function B in all those processes.

There are still some "regulator activity" terms in the function ontology, but we are working on moving them into process for the reasons above, and also because 'xxx regulator activity' doesn't give you any concrete idea of what a gene product is actually doing to bring about this regulation.

Original comment by: girlwithglasses

[gocentral]

• status: closed --> closed-rejected

Original comment by: girlwithglasses

[gocentral]

Logged In: YES user_id=735846

Thanks, yes I see the logic in that. :-)

Jen

Original comment by: jenclark