NTR - metabolism: [paxilline biosynthetic process]

[marcfeuermann]

I would only create the biosynthesis term since in general there are no degradation pathways of these metabolites (only few exceptions). No regulation terms, it was not characterized yet.

"paxilline biosynthetic process"

ChEBI Name: paxilline ChEBI ID: CHEBI:34907

Definition: The chemical reactions and pathways resulting in the formation of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels .

PMID: 23949005

Gene product names and IDs to be annotated to this term:

paxG Q9C446 Rhea:22408 paxC Q9C448 No Rhea yet paxM Q9C447 No Rhea yet paxB E3UBL6 No Rhea yet
paxP Q9C449 No Rhea yet
paxQ Q9C450 No Rhea yet
paxD Q9C451 No Rhea yet

Parent terms: GO:0016102 diterpenoid biosynthetic process GO:0043386 mycotoxin biosynthetic process

Synonyms: paxilline synthesis, paxilline biosynthesis, paxilline formation, paxilline anabolism (EXACT)

Child terms: None

Cross-references MetaCyc: PWY-7493 KEGG: www.genome.jp/dbget-bin/www_bfind_sub?mode=bfind&max_hit=1000&dbkey=kegg&keywords=paxilline

Taxon constraint: Only in taxon 4751 Fungi

Thanks a lot. Best regards, Marc.

• FOR ONTOLOGY EDITOR

• Logical definition

• • substance metabolic process: 'metabolic process' and ('has primary input or output' some [substance]
• • substance biosynthetic process: 'biosynthetic process' and ('has primary output' some [substance].
• • substance catabolic process: 'catabolic process' and ('has primary output' some [substance]

• Standard synonyms

• • substance metabolic process:
• • • EXACT: substance metabolism
• • substance biosynthetic process:
• • • EXACT: substance anabolism
• • • EXACT: substance biosynthesis
• • • EXACT: substance formation
• • • EXACT: substance synthesis
• • substance catabolic process:
• • • EXACT: substance breakdown
• • • EXACT: substance catabolism
• • • EXACT: substance degradation

[pgaudet]

+[Term] +id: GO:0140873 +name: paxilline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels." [PMID:23949005] +synonym: "paxilline anabolism" EXACT [] +synonym: "paxilline biosynthesis" EXACT [] +synonym: "paxilline formation" EXACT [] +synonym: "paxilline synthesis" EXACT [] +xref: MetaCyc:PWY-7493 +is_a: GO:0043386 ! mycotoxin biosynthetic process +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/23590 xsd:anyURI +created_by: pg +creation_date: 2022-07-05T07:12:13Z +

[pgaudet]

Need to add LD