Merge 'envenomation resulting in modulation of cell migration in another organism' into parent 'modulation of cell migration in another organism'

[pgaudet]

• [x] GO:0044624 envenomation resulting in modulation of cell migration in another organism ==> GO:0044621 modulation of cell migration in another organism
• [x] GO:0044625 envenomation resulting in negative regulation of cell migration in another organism ==> GO:0044622 negative regulation of cell migration in another organism => change label to suppression of cell migration in another organism
• [x] GO:0044626 envenomation resulting in positive regulation of cell migration in another organism ==> GO:0044623 positive regulation of cell migration in another organism => change label to induction of cell migration in another organism

[pgaudet]

Need to find references - the papers cited dont clearly talk about the toxin modulating cell migration under physiological conditions:

• PMID:16772304 (annotation to GO:0044621 modulation of cell migration in another organism
• PMID:19932752 cited for GO:0044624 envenomation resulting in modulation of cell migration in another organism It seems like some doses of the venom modulate cell migration, but the papers are looking for anti-cancer drugs or wound healing drugs (that stimulate macrophage infiltration).

[pgaudet]

• [ ] Also, @FJungo will help looks for physiological examples of 'GO:0044621 modulation of cell migration in another organism:

this term is not precise enough to know what process is being disrupted: epithelial cell migration /wound healing? macrophage migration / immune response

@genegodbold @pmasson55 @mgiglio99 @dsiegele

Do you have examples of modulation of host cell migration for bacteria/viruses?

[genegodbold]

@pgaudet What counts as modulation of migration? Lots of bacterial virulence factors paralyze phagocytes like macrophages by messing with their cytoskeleton. This usually abolishes the ability to move/migrate.

Other factors affect the chemokine environment so that they don't move as they would in the absence of those virulence factors. There are secreted Streptococcal proteases that cleave interleukin-8 and complement inflammatory mediators like C5a so that the host neutrophils "lose" coordination of the response with deleterious effects on the host.

Is this modulation of migration? I count the former as anti-phagocytic and use terms like PATHGO:0000232 (suppresses phagocytosis in another organism) OR PATHGO:0000231 (suppresses opsonization in another organism)

I also use PathGO terms specifying what aspect of the host cell cytoskeleton is disabled 'in another organism' PATHGO:0000028 (modulates cytoskeleton dynamics in another organism)

• PATHGO:0000216 (mediates filamentous actin depolymerization in another organism)
• PATHGO:0000260 (mediates filamentous actin rearrangement in another organism)
• PATHGO:0000261 (mediates actin polymerization in another organism)
• PATHGO:0000217 (mediates actin crosslinking in another organism)
• PATHGO:0000340 (mediates actin stabilization in another organism)
• PATHGO:0000378 (mediates filamentous actin destabilization in another organism)
• PATHGO:0000221 (mediates microtubule stabilization in another organism)
• PATHGO:0000222 (mediates microtubule destabilization in another organism)
• PATHGO:0000280 (mediates microtubule rearrangement in another organism)

[pgaudet]

Nice! These are much more specific. Thanks for pointing this out.

[FJungo]

Hi @pgaudet I reviewed all references linked to "cell migration" in UP entries of venoms, and found nothing physiological. Most of proteins were tested to find anti-cancer drugs. I suggest to definitely suppress the term "envenomation resulting ... cell migration in another organism".